1,209 results found
    1. Ecology
    2. Neuroscience

    Burst muscle performance predicts the speed, acceleration, and turning performance of Anna’s hummingbirds

    Paolo S Segre, Roslyn Dakin ... Douglas L Altshuler
    Maneuverability is thought to be limited by either intrinsic constraints or physiological capacity, and automated tracking of flying hummingbirds reveals that muscle capacity explains much of the variation in their flight trajectories.
    1. Stem Cells and Regenerative Medicine

    Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

    Saleh Omairi, Antonios Matsakas ... Ketan Patel
    The concepts that oxidative muscle fibres cannot be large and that satellite cell number is the major determinant for effective regeneration are fundamentally challenged.
    1. Stem Cells and Regenerative Medicine

    Inhibition of type I PRMTs reforms muscle stem cell identity enhancing their therapeutic capacity

    Claudia Dominici, Oscar D Villarreal ... Stéphane Richard
    Inhibition of type I PRMTs increases the proliferation capabilities of MuSCs with altered cellular metabolism, while maintaining their stem-like properties such as self-renewal and engraftment potential.
    1. Medicine

    Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge

    Anirban Sinha, René Lutter ... Edgar Delgado Eckert
    Fluctuation of biomarkers is a novel way of studying system stability during stable and unstable states of health and disease, revealing the systems' ability to cope with external perturbations.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Role of oxidation of excitation-contraction coupling machinery in age-dependent loss of muscle function in Caenorhabditis elegans

    Haikel Dridi, Frances Forrester ... Andrew Marks
    The Ryanodine receptor type 1 calcium channels play a critical role in age-related muscle function loss.
    1. Stem Cells and Regenerative Medicine

    Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency

    Sheryl Southard, Ju-Ryoung Kim ... Christoph Lepper
    For skeletal muscle in mice, the size of the stem cell pool can be uncoupled from overall tissue size allowing for a dramatic increase in stem cell number.
    1. Epidemiology and Global Health

    Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

    Ceereena Ubaida-Mohien, Sally Spendiff ... Russell T Hepple
    Skeletal muscle from world-class octogenarian athletes, representing a population with very high physical function in advanced age, exhibits greater mass and strength that is associated with overrepresentation of proteins involved in mitochondrial biology and more oxidatively competent muscle fibers.
    1. Cancer Biology

    The role of TAp63γ and P53 point mutations in regulating DNA repair, mutational susceptibility and invasion of bladder cancer cells

    Hsiang-Tsui Wang, Hyun-Wook Lee ... Moon-shong Tang
    Biochemical analysis shows that muscle-invasive-bladder-cancer cells are deficient in DNA repair and hypermutable, non-muscle-invasive-bladder-cancer cells are proficient in DNA repair, DNA repair capacity is regulated by tumor suppressor TAp63g, and cell invasions are regulated by TAp63g and p53.
    1. Cell Biology
    2. Developmental Biology

    Osteocytes regulate senescence of bone and bone marrow

    Peng Ding, Chuan Gao ... Junjie Gao
    Partial ablation of osteocytes alters lineage cell specifications in bone and bone marrow, resulting in the acceleration of skeletal aging.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Requirement of myomaker-mediated stem cell fusion for skeletal muscle hypertrophy

    Qingnian Goh, Douglas P Millay
    Myomaker is activated on muscle stem cells to promote their fusion with myofibers, which is essential for induction of pro-growth signaling pathways and physiological muscle hypertrophy.

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