1,447 results found
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structures reveal specialization at the myosin VI-actin interface and a mechanism of force sensitivity

    Pinar S Gurel, Laura Y Kim ... Gregory M Alushin
    Cryo-EM structures of actomyosin VI in multiple nucleotide states reveal a unique actin-myosin interface and a mechanism of force-sensitivity; furthermore, myosin VI remodels F-actin, suggesting a role for actin structural plasticity during force generation.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Small molecule-mediated refolding and activation of myosin motor function

    Michael B Radke, Manuel H Taft ... Dietmar J Manstein
    The small molecule EMD 57033 is one of a new class of pharmacological chaperones that stabilize, enhance the activity of, and correct stress-induced misfolding of myosin proteins.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

    Artur Meller, Jeffrey M Lotthammer ... Gregory R Bowman
    A cryptic pocket in the myosin motor domain selectively opens in molecular dynamics simulations, and the probability of pocket opening is predictive of how potently a compound will inhibit a particular myosin motor.
    1. Cell Biology

    TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

    Karen Baker, Irene A Gyamfi ... Daniel P Mulvihill
    IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Myosin with hypertrophic cardiac mutation R712L has a decreased working stroke which is rescued by omecamtiv mecarbil

    Aaron Snoberger, Bipasha Barua ... E Michael Ostap
    Mechanochemical defects of a β-cardiac myosin mutation that results in severe hypertrophic cardiomyopathy are reported and the heart failure drug omecamtiv mecarbil rescues these defects.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Tuning myosin-driven sorting on cellular actin networks

    Rizal F Hariadi, Ruth F Sommese, Sivaraj Sivaramakrishnan
    Competition between the antagonistic motor proteins myosin V and myosin VI finely tunes unidirectional transport of cargo on different actin architectures.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Full-length Plasmodium falciparum myosin A and essential light chain PfELC structures provide new anti-malarial targets

    Dihia Moussaoui, James P Robblee ... Anne Houdusse
    The structure of full-length myosin A provides some hints about its atypical mechanism, and reveals that the light chain PfELC is a target to block malaria pathogenesis.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties

    Luca Melli, Neil Billington ... James R Sellers
    Individual nonmuscle myosin 2 filaments in cells may differ their mechanical and kinetic properties depending on the myosin paralog composition giving the cells a mechanism for fine tuning the output of a given nonmuscle myosin filament.
    1. Cell Biology
    2. Plant Biology

    Myosin VIII associates with microtubule ends and together with actin plays a role in guiding plant cell division

    Shu-Zon Wu, Magdalena Bezanilla
    Class VIII myosins mediate crosstalk between actin and microtubules to position cell division in plants.
    1. Structural Biology and Molecular Biophysics

    Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

    Guijun Shang, Chad A Brautigam ... Xuewu Zhang
    PlexinD1 binding releases GIPC autoinhibition, leading to formation of high-order oligomers of the GIPC/myosin VI complex.

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