4,376 results found
    1. Ecology
    2. Plant Biology

    Natural genetic variation in Arabidopsis thaliana defense metabolism genes modulates field fitness

    Rachel Kerwin, Julie Feusier ... Daniel J Kliebenstein
    Environmental heterogeneity may contribute to the high levels of genetic variation in glucosinolate genes found in Arabidopsis thaliana.
    1. Genetics and Genomics

    Natural variation in the consequences of gene overexpression and its implications for evolutionary trajectories

    DeElegant Robinson, Michael Place ... Audrey P Gasch
    The genetic background of Saccharomyces cerevisiae yeast strains influences responses to gene overexpression.
    1. Genetics and Genomics

    Evolution of natural lifespan variation and molecular strategies of extended lifespan in yeast

    Alaattin Kaya, Cheryl Zi Jin Phua ... Vadim N Gladyshev
    Analysis of molecular signatures of lifespan variation across wild yeast isolates revealed how Nature employs environment to modify genotype, gene expression, and metabolome to arrive at different lifespan, while preserving fitness in various ecological niches.
    1. Genetics and Genomics
    2. Plant Biology

    Natural epigenetic polymorphisms lead to intraspecific variation in Arabidopsis gene imprinting

    Daniela Pignatta, Robert M Erdmann ... Mary Gehring
    Individual scientists, scientific communities and scientific journals can do more to assess the publication of irreproducible results, to promote good science, and to increase the efficiency with which the scientific community self-corrects.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A modified fluctuation assay reveals a natural mutator phenotype that drives mutation spectrum variation within Saccharomyces cerevisiae

    Pengyao Jiang, Anja R Ollodart ... Kelley Harris
    Certain mutational signatures vary in their contribution to genetic variation across the yeast phylogeny due to genetically encoded natural mutator phenotypes whose activity can be directly measured in the lab.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Characterization of sequence determinants of enhancer function using natural genetic variation

    Marty G Yang, Emi Ling ... Thomas Vierbuchen
    Large-scale, allele-resolved mapping of cis-regulatory function in F1-hybrid mice reveals sequence determinants that control transcription factor binding and enhancer activity in native chromatin context.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Natural variation in C. elegans arsenic toxicity is explained by differences in branched chain amino acid metabolism

    Stefan Zdraljevic, Bennett William Fox ... Erik C Andersen
    Quantitative genetics approaches using Caenorhabditis elegans facilitate the discovery of a novel arsenic toxicity mechanism.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes

    Jo Hepworth, Rea L Antoniou-Kourounioti ... Caroline Dean
    Variation in autumnal expression from starting expression levels and initial cold-down-regulation, rather than epigenetic silencing, is the major field variable conferred by worldwide haplotypes of the floral repressor gene, FLC.
    1. Genetics and Genomics

    Natural variation in sugar tolerance associates with changes in signaling and mitochondrial ribosome biogenesis

    Richard G Melvin, Nicole Lamichane ... Ville Hietakangas
    The optimal macronutrient composition, macronutrient space, varies strongly between closely related species and is determined by genetic changes in regulatory genes that globally reprogram gene expression profiles of metabolic pathways.
    1. Computational and Systems Biology
    2. Plant Biology

    An ABA-GA bistable switch can account for natural variation in the variability of Arabidopsis seed germination time

    Katie Abley, Pau Formosa-Jordan ... James CW Locke
    Arabidopsis shows extensive genetic diversity in germination time distributions, which can be explained by the underlying ABA/GA network functioning as a noisy bistable switch.

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