114 results found
    1. Developmental Biology

    Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

    Dorit Hockman, Alan J Burns ... Clare V H Baker
    Embryonic fate-mapping approaches in zebrafish, Xenopus and lamprey illuminate the evolutionary origins of carotid body glomus cells and pulmonary neuroendocrine cells.
    1. Developmental Biology
    2. Physics of Living Systems

    The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism

    David J Jörg, Elizabeth E Caygill ... Benjamin D Simons
    A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration

    Aida Rodrigo Albors, Akira Tazaki ... Elly M Tanaka
    During axolotl spinal cord regeneration adult neural stem cells reactivate an embryonic neuroepithelial cell-like gene program that implements planar cell polarity to orient cell divisions, coupling polarized spinal cord growth with stem cell self-renewal.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Engineering induction of singular neural rosette emergence within hPSC-derived tissues

    Gavin T Knight, Brady F Lundin ... Randolph Scott Ashton
    A bioengineering approach identifies tissue morphology as an effective variable for controlling the inception of neural organoid morphogenesis via induction of a biomimetic, singular neural rosette tissue cytoarchitecture.
    1. Developmental Biology

    Inter-dependent apical microtubule and actin dynamics orchestrate centrosome retention and neuronal delamination

    Ioannis Kasioulis, Raman M Das, Kate G Storey
    Microtubules are nucleated by the centrosome of the primary cilium in the apical end-foot of neuroepithelial cells and inter-dependent microtubule and actin dynamics are required here to orchestrate delamination of newborn neurons.
    1. Cell Biology
    2. Developmental Biology

    Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis

    Jaydeep Sidhaye, Caren Norden
    Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
    1. Developmental Biology

    A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus

    Kavitha Chinnaiya, Sarah Burbridge ... Marysia Placzek
    Fate-mapping, combined with gain- and loss-of-function approaches, reveal the role of BMP signalling in the spatio-temporal development of the tuberal hypothalamus, a critically important brain region.
    1. Cell Biology

    A bioactive peptide amidating enzyme is required for ciliogenesis

    Dhivya Kumar, Daniela Strenkert ... Betty A Eipper
    Analysis of Chlamydomonas, planaria and mice reveals a novel and unanticipated role for a peptide amidating enzyme in primary and motile ciliary assembly through effects on post-Golgi trafficking.
    1. Developmental Biology

    Generation of the squamous epithelial roof of the 4th ventricle

    Florent Campo-Paysaa, Jonathan DW Clarke, Richard JT Wingate
    A new cell type at the border of the fourth ventricle is the exclusive source of roof plate.
    1. Developmental Biology

    LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

    Hyang Mi Moon, Simon Hippenmeyer ... Anthony Wynshaw-Boris
    Novel insights into LIS1-dependent regulation of cell membrane contractility and cleavage axis specification identify a key molecular network regulating mitoses of neural progenitors and somatic cells during development.

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