1,940 results found
    1. Neuroscience

    The critical role of membralin in postnatal motor neuron survival and disease

    Bo Yang, Mingliang Qu ... Dongxian Zhang
    Membralin mutant mice manifest a severe and early-onset motor neuron disease with defects in endoplasmic reticulum-associated protein degradation.
    1. Neuroscience

    A Toll-receptor map underlies structural brain plasticity

    Guiyi Li, Manuel G Forero ... Alicia Hidalgo
    Structural brain plasticity is encoded in the topographic distribution of Toll receptors and their ability to switch between alternative signalling outcomes, thus translating diverse sensory experience into structural change.
    1. Neuroscience

    Optimal compensation for neuron loss

    David GT Barrett, Sophie Denève, Christian K Machens
    Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
    1. Neuroscience

    Molecular characterization of projection neuron subtypes in the mouse olfactory bulb

    Sara Zeppilli, Tobias Ackels ... Alexander Fleischmann
    Different subtypes of projection neurons in the mouse olfactory bulb are defined by distinct gene expression patterns and transcription factor networks.
    1. Stem Cells and Regenerative Medicine

    Systemic and local cues drive neural stem cell niche remodelling during neurogenesis in Drosophila

    Pauline Spéder, Andrea H Brand
    Cross talk between neural stem cells and their glial niche enables the niche to adapt to the evolving needs of the stem cells throughout development.
    1. Genetics and Genomics

    The landscape of m1A modification and its posttranscriptional regulatory functions in primary neurons

    Chi Zhang, Xianfu Yi ... Hengxing Zhou
    The m1A modification plays vital roles in the regulation of the biological functions of multiple RNA species (including mRNA, lncRNA, and circRNA) and influences the interactions between these RNAs.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

    Markus Terrey, Scott I Adamson ... Susan L Ackerman
    The translational GTPase GTPBP1 prevents ribosome stalling during tRNA deficiency and is necessary for neuronal survival.
    1. Developmental Biology

    tec-1 kinase negatively regulates regenerative neurogenesis in planarians

    Alexander Karge, Nicolle A Bonar ... Christian P Petersen
    RNAi screening in planarians finds that inhibition of the TEC-family protein tyrosine kinase tec-1 increases the regeneration of neurons through enhancement of cell survival.
    1. Developmental Biology
    2. Neuroscience

    Targeted molecular profiling of rare olfactory sensory neurons identifies fate, wiring, and functional determinants

    J Roman Arguello, Liliane Abuin ... Richard Benton
    Targeted expression of molecular probes for gene expression and chromatin accessibility in subpopulations of neurons in the Drosophila olfactory system identifies genes required for their development and function.
    1. Developmental Biology
    2. Neuroscience

    Differentiation signals from glia are fine-tuned to set neuronal numbers during development

    Anadika R Prasad, Inês Lago-Baldaia ... Vilaiwan M Fernandes
    Extrinsic signals establish an invariant and stereotyped pattern of neuronal differentiation and programmed cell death in the Drosophila visual system.

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