198 results found
    1. Neuroscience

    Plasmon resonance and the imaging of metal-impregnated neurons with the laser scanning confocal microscope

    Karen J Thompson, Cynthia M Harley ... Karen A Mesce
    A new method allows silver- and gold-labeled tissues to be imaged with confocal microscopy, avoiding the problem of fluorescence photobleaching.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ

    Zhi Yang Tan, Shujun Cai ... Lu Gan
    Nucleosomes inside of baker’s yeast cells largely do not resemble those found in test tubes.
    1. Evolutionary Biology
    2. Plant Biology

    Environment as a limiting factor of the historical global spread of mungbean

    Pei-Wen Ong, Ya-Ping Lin ... Cheng-Ruei Lee
    After domestication, the cultivation range expansion of crops was not solely dictated by human activity but instead constrained by climatic factors, which in turn resulted in distinct phenotypic characteristics of locally adaptive landraces.
    1. Structural Biology and Molecular Biophysics

    Routine single particle CryoEM sample and grid characterization by tomography

    Alex J Noble, Venkata P Dandey ... Bridget Carragher
    Fiducial-less tomography on single particle cryoEM samples reveals that most particles are adsorbed to the air-water interface and allows for researchers to diagnose and solve sample, grid, ice thickness, collection, and processing issues.
    1. Cell Biology
    2. Medicine

    Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosis

    Jiurong Liang, Guanling Huang ... Dianhua Jiang
    The synergy between aging and injury impairs alveolar progenitor functions leading to progressive lung fibrosis.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structure of the gene therapy vector, adeno-associated virus with its cell receptor, AAVR

    Nancy L Meyer, Guiqing Hu ... Michael Stewart Chapman
    Cryo-electron microscopy reveals interactions at the interface between adeno-associated virus and its cellular receptor at 2.4Å resolution.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanisms of opening and closing of the bacterial replicative helicase

    Jillian Chase, Andrew Catalano ... David Jeruzalmi
    Analysis of the Escherichia coli DnaB helicase•bacteriophage λ helicase loader (λP) complex provides insights into helicase opening, delivery to the origin and ssDNA entry, and closing in preparation for translocation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The dynamic three-dimensional organization of the diploid yeast genome

    Seungsoo Kim, Ivan Liachko ... Maitreya J Dunham
    Yeast homologous chromosomes exhibit condition-specific mitotic pairing at both global and local scales.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Selfing is the safest sex for Caenorhabditis tropicalis

    Luke M Noble, John Yuen ... Matthew V Rockman
    Out breeding depression in Caenorhabditis tropicalis is due to common maternal-offspring incompatibilities that interact with a highly heterogeneous genetic background and may provide a short-term advantage to inbreeding.
    1. Ecology
    2. Evolutionary Biology

    Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications

    Susanne RK Zajitschek, Felix Zajitschek ... Shinichi Nakagawa
    Sex differences in trait variability imply that both sexes should be included in biomedical trials, using sex-specific statistical power calculations.

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