I Lorena Arancibia-Cárcamo, Marc C Ford ... David Attwell
Node of Ranvier length is similar at successive nodes along single myelinated CNS axons, but differs between axons, and could potentially be tuned to adjust the conduction velocity of each axon.
Stephen G Brohawn, Weiwei Wang ... Roderick MacKinnon
The mechanosensitive potassium channel TRAAK is localized to nodes of Ranvier is mammalian axons where it hyperpolarizes the resting potential and may contribute to mechanical repolarization of neurons.
Elise LV Malavasi, Aniket Ghosh ... Peter J Brophy
Dynamic early clusters of nodal proteins in peripheral nerves represent a neurofascin-dependent developmental stage of node assembly during myelination that precedes heminode formation.
Ashtyn T Wiltbank, Emma R Steinson ... Sarah Kucenas
Cd59 and developmental inflammation are key players in myelinating glial cell development, highlighting the collaboration between glia and the innate immune system to ensure normal neural development.
Single and double-knockout mouse models for proteins associated with nodes of Ranvier reveal that a paranodal, spectrin-based lateral diffusion barrier is sufficient to cluster Na+ channels at nodes of Ranvier.