162 results found
    1. Neuroscience

    Node of Ranvier length as a potential regulator of myelinated axon conduction speed

    I Lorena Arancibia-Cárcamo, Marc C Ford ... David Attwell
    Node of Ranvier length is similar at successive nodes along single myelinated CNS axons, but differs between axons, and could potentially be tuned to adjust the conduction velocity of each axon.
    1. Neuroscience

    The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier

    Stephen G Brohawn, Weiwei Wang ... Roderick MacKinnon
    The mechanosensitive potassium channel TRAAK is localized to nodes of Ranvier is mammalian axons where it hyperpolarizes the resting potential and may contribute to mechanical repolarization of neurons.
    1. Neuroscience

    Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons

    Elise LV Malavasi, Aniket Ghosh ... Peter J Brophy
    Dynamic early clusters of nodal proteins in peripheral nerves represent a neurofascin-dependent developmental stage of node assembly during myelination that precedes heminode formation.
    1. Developmental Biology
    2. Neuroscience

    Cd59 and inflammation regulate Schwann cell development

    Ashtyn T Wiltbank, Emma R Steinson ... Sarah Kucenas
    Cd59 and developmental inflammation are key players in myelinating glial cell development, highlighting the collaboration between glia and the innate immune system to ensure normal neural development.
    1. Neuroscience

    Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

    Naomi AK Hanemaaijer, Marko A Popovic ... Maarten HP Kole
    High-speed calcium imaging from the axon initial segment shows that sodium channels are in part permeable to calcium ions.
    1. Neuroscience

    Dipolar extracellular potentials generated by axonal projections

    Thomas McColgan, Ji Liu ... Richard Kempter
    Action potentials propagating in axon bundles with bifurcating and terminating fibers cause strong and far-reaching extracellular potentials.
    1. Neuroscience

    The paranodal cytoskeleton clusters Na+ channels at nodes of Ranvier

    Veronique Amor, Chuansheng Zhang ... Elior Peles
    Single and double-knockout mouse models for proteins associated with nodes of Ranvier reveal that a paranodal, spectrin-based lateral diffusion barrier is sufficient to cluster Na+ channels at nodes of Ranvier.
    1. Neuroscience

    β spectrin-dependent and domain specific mechanisms for Na+ channel clustering

    Cheng-Hsin Liu, Ryan Seo ... Matthew N Rasband
    β4 spectrin is required to maintain Na+ channels at the axon initial segment since, unlike nodes of Ranvier, β1 spectrin cannot substitute.
    1. Cell Biology
    2. Neuroscience

    TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells

    Kae-Jiun Chang, Ira Agrawal ... Jonah R Chan
    Glial TDP-43 regulates splicing and expression of neurofascin and is required for proper assembly and maintenance of paranodal axoglial junctions.
    1. Developmental Biology
    2. Neuroscience

    Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

    Xin Zhou, Seula Shin ... Jian Hu
    Qki-Srebp2–mediated cholesterol biosynthesis is indispensable for myelinogenesis during early brain development.

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