Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz
Activation of Notch receptors by ligands in the same cell (cis-activation) is a prevalent and functional mode of signaling in the Notch pathway, and co-exists with trans-activation and cis-inhibition.
Steven W Miller, Artem Movsesyan ... James W Posakony
Hairless emerged as an evolutionarily novel regulatory protein that replaced an ancestral paradigm of direct co-repressor recruitment by Suppressor of Hairless, its partner transcription factor in the Notch signaling pathway.
Sergio Menchero, Isabel Rollan ... Miguel Manzanares
The Notch signaling pathway drives transitions in differentiation capacities during the gradual loss of potency that occurs in the preimplantation mouse embryo before the onset of the first lineage decisions.
A quantitative live imaging approach unveils that earliest neurogenic progenitors in the vertebrate retina arise from asymmetric divisions and that this asymmetry involves Notch signalling through the endocytic pathway.
Fringe proteins modulate cis inhibitory, same-cell interactions between the Notch receptor and its ligands to control whether, and in which direction, cells can signal to one another.
Vishnu Muraleedharan Saraswathy, Akshai Janardhana Kurup ... Maximilian Fürthauer
Mindbomb1 acts independently of it well-known role in Notch signalling to control the endocytic internalization of the Wnt co-receptor Ryk and thereby modulate the activity of the Planar Cell Polarity pathway that governs morphogenetic movements during embryonic development.