743 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    Cis-activation in the Notch signaling pathway

    Nagarajan Nandagopal, Leah A Santat, Michael B Elowitz
    Activation of Notch receptors by ligands in the same cell (cis-activation) is a prevalent and functional mode of signaling in the Notch pathway, and co-exists with trans-activation and cis-inhibition.
    1. Cell Biology
    2. Developmental Biology

    Notch signaling restricts FGF pathway activation in parapineal cells to promote their collective migration

    Lu Wei, Amir Al Oustah ... Myriam Roussigné
    Notch signaling controls the collective migration of parapineal cells through its capacity to restrict FGF pathway activation to a few leading cells.
    1. Developmental Biology
    2. Evolutionary Biology

    Evolutionary emergence of Hairless as a novel component of the Notch signaling pathway

    Steven W Miller, Artem Movsesyan ... James W Posakony
    Hairless emerged as an evolutionarily novel regulatory protein that replaced an ancestral paradigm of direct co-repressor recruitment by Suppressor of Hairless, its partner transcription factor in the Notch signaling pathway.
    1. Stem Cells and Regenerative Medicine

    Tgfb3 collaborates with PP2A and notch signaling pathways to inhibit retina regeneration

    Mi-Sun Lee, Jin Wan, Daniel Goldman
    Tgfb3 inhibits Muller glial cell reprogramming and drives Muller cell quiescence in the injured zebrafish retina, thereby inhibiting retina regeneration.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Transitions in cell potency during early mouse development are driven by Notch

    Sergio Menchero, Isabel Rollan ... Miguel Manzanares
    The Notch signaling pathway drives transitions in differentiation capacities during the gradual loss of potency that occurs in the preimplantation mouse embryo before the onset of the first lineage decisions.
    1. Cell Biology
    2. Developmental Biology

    Cis-interactions between Notch and its ligands block ligand-independent Notch activity

    William Hunt Palmer, Dongyu Jia, Wu-Min Deng
    Notch ligands expressed in the same cell as the Notch receptor are crucial to prevent accidental, ligand-independent Notch activity.
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    1. Developmental Biology

    Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway

    Elisa Nerli, Mauricio Rocha-Martins, Caren Norden
    A quantitative live imaging approach unveils that earliest neurogenic progenitors in the vertebrate retina arise from asymmetric divisions and that this asymmetry involves Notch signalling through the endocytic pathway.
    1. Developmental Biology

    Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

    Lauren LeBon, Tom V Lee ... Michael B Elowitz
    Fringe proteins modulate cis inhibitory, same-cell interactions between the Notch receptor and its ligands to control whether, and in which direction, cells can signal to one another.
    1. Developmental Biology

    The E3 ubiquitin ligase mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation

    Vishnu Muraleedharan Saraswathy, Akshai Janardhana Kurup ... Maximilian Fürthauer
    Mindbomb1 acts independently of it well-known role in Notch signalling to control the endocytic internalization of the Wnt co-receptor Ryk and thereby modulate the activity of the Planar Cell Polarity pathway that governs morphogenetic movements during embryonic development.
    1. Cell Biology
    2. Developmental Biology

    The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis

    Diana M Ho, SK Pallavi, Spyros Artavanis-Tsakonas
    A diverse group of modifier genes, including the proto-oncogene Src, cooperate with Notch specifically to control cell proliferation.

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