156 results found
    1. Cell Biology
    2. Developmental Biology

    Notochord vacuoles absorb compressive bone growth during zebrafish spine formation

    Jennifer Bagwell, James Norman ... Michel Bagnat
    Live imaging and genetic analyses revealed that notochord vacuoles play a critical role in spine morphogenesis by absorbing vertebral bone growth, thus implicating notochord mechanics in congenital scoliosis.
    1. Developmental Biology
    2. Evolutionary Biology

    Xbp1 and Brachyury establish an evolutionarily conserved subcircuit of the notochord gene regulatory network

    Yushi Wu, Arun Devotta ... Anna Di Gregorio
    Research carried out in the simple chordate Ciona has elucidated the regulatory interplay between two evolutionarily conserved transcription factors, Brachyury and Xbp1, and has shed new light on their roles in the formation of the notochord.
    1. Developmental Biology

    Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

    Héctor Sánchez-Iranzo, Aliaksandr Halavatyi, Alba Diz-Muñoz
    Interaction strength in Notch signaling determines lateral inhibition patterning and drives fate in the unidimensional cell arrangement of the zebrafish notochord.
    1. Developmental Biology

    Segmentation of the zebrafish axial skeleton relies on notochord sheath cells and not on the segmentation clock

    Laura Lleras Forero, Rachna Narayanan ... Stefan Schulte-Merker
    In contrast to amniotes, zebrafish (ray-finned fish, teleost) centra are formed from specialised notochord sheath cells, and the segmental patterning of these cells is independent of the segmentation clock.
    1. Stem Cells and Regenerative Medicine

    Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair

    Juan Carlos Lopez-Baez, Daniel J Simpson ... E Elizabeth Patton
    Wound-specific notochord sheath cell subpopulations associate with notochord repair and adult vertebrae formation.
    1. Developmental Biology

    Reciprocal and dynamic polarization of planar cell polarity core components and myosin

    Erin Newman-Smith, Matthew J Kourakis ... William C Smith
    Planar cell polarity (PCP) components and myosin show a parallel temporal polarization in the Ciona notochord and the mutual interaction between these proteins is required for proper tissue-wide polarity.
    1. Developmental Biology

    Notochord: Patterning the spine

    Matthew P Harris, Gloria Arratia
    Experiments have shed new light on the development of the spine in zebrafish.
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    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Assembly and positioning of actomyosin rings by contractility and planar cell polarity

    Ivonne M Sehring, Pierre Recho ... Di Jiang
    Contractility wins over the polarity pathway in a tug-of-war to position a cytokinesis-like actomyosin ring at the equator of notochord cells.
    1. Developmental Biology
    2. Structural Biology and Molecular Biophysics

    Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation

    David R Shook, Eric M Kasprowicz ... Raymond Keller
    Blastopore closure in Xenopus is driven by two morphogenic mechanisms that have strongly context dependent effects on tissue movement and that generate tensile force across tissues: convergent extension, as expected, and, unexpectedly, convergent thickening.
    1. Developmental Biology

    Regulation of posterior body and epidermal morphogenesis in zebrafish by localized Yap1 and Wwtr1

    David Kimelman, Natalie L Smith ... Didier YR Stainier
    Analysis of a double mutant in the Hippo pathway transcription factors Yap1 and Wwtr1 reveals novel roles for these factors in posterior body formation and epidermal morphogenesis in the vertebrate embryo.

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