369 results found
    1. Cancer Biology
    2. Genetics and Genomics

    Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

    Tong Xu, Mathijs Verhagen ... Riccardo Fodde
    The identification of alternative splicing targets and upstream RNA-binding proteins that underlie EMT and metastasis in colon cancer stratifies patients according to their overall survival and provide new insights on the function of specific isoforms along the migrating cancer stem cell sequence.
    1. Developmental Biology

    Precardiac deletion of Numb and Numblike reveals renewal of cardiac progenitors

    Lincoln T Shenje, Peter Andersen ... Chulan Kwon
    Cardiac progenitors remain undifferentiated and expansive in the second pharyngeal arch that serves as a microenvironment, and Numb and Numblike are required for their renewal.
    1. Cell Biology
    2. Developmental Biology

    NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures

    Lindsey Seldin, Andrew Muroyama, Terry Lechler
    A newly identified microtubule binding activity of NuMA is required for orienting the mitotic spindle.
    1. Cell Biology

    Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

    Masako Okumura, Toyoaki Natsume ... Tomomi Kiyomitsu
    Optogenetic reconstitution reveals core functional modules and architecture of the cortical force-generating machinery in human cells.
    1. Cell Biology

    NuMA recruits dynein activity to microtubule minus-ends at mitosis

    Christina L Hueschen, Samuel J Kenny ... Sophie Dumont
    At mitosis, NuMA recruits dynein-dynactin to microtubule minus-ends, enabling robust microtubule clustering and the emergence of spindle poles.
    1. Cell Biology

    Septin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function

    Rita De Gasperi, Laszlo Csernoch ... Christopher P. Cardozo
    1. Cell Biology

    Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1

    Safia Omer, Samuel R Greenberg, Wei-Lih Lee
    Dynein-dependent microtubule-cortex interactions – "side-on" versus "end-on" pulling – are regulated by cortical ER and mediated by distinct pools of cortical anchor that are differentially localized along the cell periphery.
    1. Neuroscience

    BNP facilitates NMB-encoded histaminergic itch via NPRC-NMBR crosstalk

    Qing-Tao Meng, Xian-Yu Liu ... Zhou-Feng Chen
    B-type natriuretic peptide (BNP) modulates itch via BNP-NPRC pathway by enhancing NMB-NMBR signaling, which is independently of gastrin-releasing peptide (GRP)-GRPR signaling in the spinal cord.
    1. Cell Biology
    2. Developmental Biology

    Optogenetic dissection of mitotic spindle positioning in vivo

    Lars-Eric Fielmich, Ruben Schmidt ... Sander van den Heuvel
    New germline gene expression, knockout, and optogenetic tools reveal essential roles for Gα-GPR-1,2/Pins as a regulatable membrane anchor and LIN-5/NuMA as an activator of cortical dynein in mitotic spindle positioning.
    1. Neuroscience

    Loss of cortical control over the descending pain modulatory system determines the development of the neuropathic pain state in rats

    Robert AR Drake, Kenneth A Steel ... Anthony E Pickering
    Alterations to brain network communication leading to a progressive loss in descending inhibitory modulation of the spinal cord is a key determinate of pain state development following peripheral nerve injury.

Refine your results by:

Type
Research categories