The activin receptor ALK7 regulates the adaptation of brown adipose tissue to nutrient availability by preventing over-activation of signaling pathways induced by fasting, allowing appropriate response to cold exposure.
Transcriptomic and genetic analyses of FoxO target genes reveal a key function of ER-associated protein degradation in growth regulation of Tsc1-deficient tissues.
General stress response factors Msn2 and Msn4 activate glycolytic genes and promote acetyl-CoA accumulation to stimulate growth and proliferation of yeast cells under a nutrient-limiting condition, suggesting the unexpected interrelationship between carbohydrate metabolism and stress response.
Juan J Apiz Saab, Lindsey N Dzierozynski ... Alexander Muir
Analysis of the tumor microenvironment reveals that pancreatic tumors experience metabolic stress caused by immune cell degradation of the amino acid arginine, and that pancreatic cancers cope by synthesizing arginine to provide access this amino acid despite low tumor availability.
Phosphate starvation in rice induces widespread, but transient, modulation of DNA methylation near stress responsive genes that is independent from the RNA-directed DNA methylation pathway.
Nicholas O Burton, Alexandra Willis ... Eric A Miska
Intergenerational adaptations to stress play a critical role in organismal responses to changing environments and are largely lost or erased after one generation.
The development of Drosophila somatosensory neurons is spared under nutrient deficiency so that they grow more dendrites and make animals more sensitive to environmental stimuli.
Food supply and nutrient stress tolerance coordinately shape the multilevel selection dynamics of a mitochondrial cheater by promoting cheater persistence at both within-host and between-host levels of selection.
Enteroendocrine cells sense nutrients in the gut and regulate digestive physiology but are rendered insensitive following fat ingestion due to alteration of gut microbiota.