705 results found
    1. Epidemiology and Global Health

    Future life expectancy in Europe taking into account the impact of smoking, obesity, and alcohol

    Fanny Janssen, Anastasios Bardoutsos ... Joop De Beer
    Accounting for the impact of smoking, obesity, and alcohol on past mortality trends, we project, compared to common practice, longer individual lifespans and more elderly in society for the future.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Maternal obesity blunts antimicrobial responses in fetal monocytes

    Suhas Sureshchandra, Brianna M Doratt ... Ilhem Messaoudi
    Maternal obesity and high-fat diet present metabolic, signaling, and epigenetic impediments to pathogen recognition in fetal innate immune cells that result in a state of immune paralysis during gestation and at birth.
    1. Immunology and Inflammation

    Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

    Zihao Yao, Weizhong Qi ... Haiyan Zhang
    Down-regulation of GAS6 by M1 macrophages resulted in impaired efferocytosis for synovial apoptotic cells, causing synovial hyperplasia and obesity-associated OA development.
    1. Medicine

    Sulforaphane reduces obesity by reversing leptin resistance

    Işın Çakır, Pauline Lining Pan ... Masoud Ghamari-Langroudi
    Sulforaphane through NRF2-dependent and -independent cellular and molecular pathways alleviates leptin resistance to reverse the diet-induced obesity.
    1. Immunology and Inflammation

    Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils

    Jiang Li, Rebecca E Ruggiero-Ruff ... Meera G Nair
    The small macrophage-secreted protein RELMα is a sex-specific protein that protects against diet-induced obesity through regulating the macrophage–eosinophil innate immune axis in the adipose tissue.
    1. Cell Biology
    2. Medicine

    Adipocyte NR1D1 dictates adipose tissue expansion during obesity

    Ann Louise Hunter, Charlotte E Pelekanou ... David A Bechtold
    Clock protein NR1D1 regulates white adipose tissue expansion and development of obesity-related pathology.
    1. Developmental Biology
    2. Genetics and Genomics

    Fat body-specific reduction of CTPS alleviates HFD-induced obesity

    Jingnan Liu, Yuanbing Zhang ... Ji-Long Liu
    Genetic interaction and biochemical analyses have unveiled the crucial involvement of CTPS in the regulation of adipocyte growth, lipid metabolism, and metabolic adaptation in Drosophila, achieved through activating the PI3K-Akt-SREBP pathway.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis

    Ayala Tovy, Jaime M Reyes ... Margaret A Goodell
    Normal adipogenesis requires de novo DNA methyltransferase 3A (DNMT3A) for proper differentiation and suppression of an age-associated pathogenic inflammatory program.
    1. Medicine

    Gut microbe-targeted choline trimethylamine lyase inhibition improves obesity via rewiring of host circadian rhythms

    Rebecca C Schugar, Christy M Gliniak ... Jonathan Mark Brown
    Small molecule inhibitors of gut microbial choline trimethylamine lyase activity protect against obesity.
    1. Cell Biology

    Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

    Jonathan Mowers, Maeran Uhm ... Alan R Saltiel
    Reduced energy expenditure in obesity may result from reduced sensitivity to sympathetic activation due to inflammation-generated signals in adipose tissue.

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