665 results found
    1. Developmental Biology
    2. Neuroscience

    Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein

    Stephan Heermann, Lucas Schütz ... Joachim Wittbrodt
    The lens-averted domains of the optic vesicle are reservoirs of neuroretinal cells that flow into the developing optic cup in a process that is critically influenced by BMP signaling.
    1. Cell Biology
    2. Developmental Biology

    Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

    María Nicolás-Pérez, Franz Kuchling ... Juan R Martínez-Morales
    High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
    1. Developmental Biology
    2. Neuroscience

    Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis

    Tania Moreno-Mármol, Mario Ledesma-Terrón ... Paola Bovolenta
    Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
    1. Cell Biology
    2. Developmental Biology

    Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis

    Jaydeep Sidhaye, Caren Norden
    Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
    1. Developmental Biology
    2. Neuroscience

    Mechanisms underlying microglial colonization of developing neural retina in zebrafish

    Nishtha Ranawat, Ichiro Masai
    Genetic and imaging analysis reveal that microglial precursors use ocular blood vessels as a pathway to enter the optic cup and subsequently infiltrate the retina preferentially through the neurogenic region.
    1. Neuroscience

    Dopamine in the dorsal bed nucleus of stria terminalis signals Pavlovian sign-tracking and reward violations

    Utsav Gyawali, David A Martin ... Donna Calu
    Dopamine signaling in the bed nucleus of stria terminalis supports sign-tracking, reinforcer-specific satiety, and encodes reward prediction errors.
    1. Developmental Biology

    Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

    Holly Hardy, James GD Prendergast ... Joe Rainger
    Chick optic fissure closure is a powerful new model system for epithelial fusion and has revealed Netrin-1 as a conserved and essential mediator of tissue fusion in multiple contexts.
    1. Neuroscience

    Monitoring ATP dynamics in electrically active white matter tracts

    Andrea Trevisiol, Aiman S Saab ... Johannes Hirrlinger
    ATP imaging of spiking optic nerve axons in real time reveals correlation between ATP levels and electrical activity as well as contribution of lactate metabolism to axonal ATP homeostasis.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Fish primary embryonic pluripotent cells assemble into retinal tissue mirroring in vivo early eye development

    Lucie Zilova, Venera Weinhardt ... Joachim Wittbrodt
    Fish-derived pluripotent cells instinctively form retinal tissue recapitulating key steps of early eye development.
    1. Neuroscience

    Distinct spatial coordinate of visual and vestibular heading signals in macaque FEFsem and MSTd

    Lihua Yang, Yong Gu
    In both frontal and temporal–parietal visual cortices of macaque, distinct spatial coordinates of visual and vestibular signals are predominantly eye centered and head centered, respectively.

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