1,072 results found
    1. Developmental Biology
    2. Neuroscience

    Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein

    Stephan Heermann, Lucas Schütz ... Joachim Wittbrodt
    The lens-averted domains of the optic vesicle are reservoirs of neuroretinal cells that flow into the developing optic cup in a process that is critically influenced by BMP signaling.
    1. Developmental Biology

    Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential mediator of epithelial fusion

    Holly Hardy, James GD Prendergast ... Joe Rainger
    Chick optic fissure closure is a powerful new model system for epithelial fusion and has revealed Netrin-1 as a conserved and essential mediator of tissue fusion in multiple contexts.
    1. Biochemistry and Chemical Biology

    GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes

    Jayashree Jena, Luis Miguel García-Peña ... Renata O Pereira
    Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.
    1. Developmental Biology
    2. Neuroscience

    Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis

    Tania Moreno-Mármol, Mario Ledesma-Terrón ... Paola Bovolenta
    Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
    1. Developmental Biology
    2. Neuroscience

    Mechanisms underlying microglial colonization of developing neural retina in zebrafish

    Nishtha Ranawat, Ichiro Masai
    Genetic and imaging analysis reveal that microglial precursors use ocular blood vessels as a pathway to enter the optic cup and subsequently infiltrate the retina preferentially through the neurogenic region.
    1. Cell Biology
    2. Developmental Biology

    Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

    María Nicolás-Pérez, Franz Kuchling ... Juan R Martínez-Morales
    High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
    1. Cell Biology
    2. Developmental Biology

    Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis

    Jaydeep Sidhaye, Caren Norden
    Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
    1. Developmental Biology
    2. Neuroscience

    Revisiting the role of Dcc in visual system development with a novel eye clearing method

    Robin J Vigouroux, Quénol Cesar ... Kim Tuyen Nguyen-Ba-Charvet
    A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.
    1. Developmental Biology
    2. Physics of Living Systems

    The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism

    David J Jörg, Elizabeth E Caygill ... Benjamin D Simons
    A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
    1. Biochemistry and Chemical Biology

    OPA1 deletion in brown adipose tissue improves thermoregulation and systemic metabolism via FGF21

    Renata O Pereira, Alex Marti ... E Dale Abel
    Lack of OPA1 in BAT impairs its thermogenic activation and induces endoplasmic reticulum stress, while improving systemic metabolism and thermoregulation via ATF4-FGF21-dependent and -independent mechanisms.

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