Stephan Heermann, Lucas Schütz ... Joachim Wittbrodt
The lens-averted domains of the optic vesicle are reservoirs of neuroretinal cells that flow into the developing optic cup in a process that is critically influenced by BMP signaling.
Tania Moreno-Mármol, Mario Ledesma-Terrón ... Paola Bovolenta
Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
The LIM-homedomain transcription factor Lhx2 confers competence to retinal progenitor cells to activate and maintain Sonic Hedgeghog signaling at physiological levels during a key phase of tissue growth and cell type generation.
Organoids are useful in studying guidance cues for retinal ganglion cell (RGC) axon generation and regeneration, and the method of RGC isolation via CNTN2 facilitates investigating RGC-related retinal diseases such as glaucoma.
In vivo time lapse imaging reveals that microglial trogocytosis of presynaptic elements is regulated by the complement system which controls axon morphogenesis in the developing brain.
Cellular and tissue level analysis reveals how different cell behaviors involving dynamics of the basal domain cooperate in space and time to shape an epithelial organ.
Yevgeniya A Mironova, Guy M Lenk ... Roman J Giger
The signaling lipid PI(3,5)P2 supports the formation of the myelin sheath, by regulating trafficking of myelin building blocks within oligodendrocytes and communication between oligodendrocytes and neuronal axons.