The combined use of optical trapping and single-molecule FRET permits the study of riboswitch structure formation and conformational dynamics at the same time.

Cardiac myosin converts energy from ATP into mechanical work by transitioning from a short-lived force-bearing state, to a post working stroke state before the release of inorganic phosphate.

A new optical tweezers assay sheds light on the mechanism of cooperation and force generation by the subunits of RecBCD, critical for the repair of double strand breaks in bacteria.

A combination of experiments, theory, and simulations shows that the elastic softening of microtubules when they are bent arises due to the flattening of their tubular cross-section.

While the transcription factor c-Myc explores the space in the nucleus in an unrestricted manner, the elongation factor P-TEFb's sampling of the nucleus is constrained to a complex domain with fractal characteristics.

Force generation by kinesin motor proteins requires formation of both a 2-stranded cover-neck bundle and an asparagine-based latch for transport of membrane-bound cargoes in cells.

Building on previous work (Syrjänen, Pellegrini, & Davies, 2014), it is shown that SYCP3 contributes to the architecture of meiotic chromosomes through local bridging interactions that result in large-scale compaction of the chromosome axis.

Two components of the inner kinetochore (OA and Mif2) are independently capable of transmitting physiologically relevant forces to a centromeric nucleosome.

Mechanochemical defects of a β-cardiac myosin mutation that results in severe hypertrophic cardiomyopathy are reported and the heart failure drug omecamtiv mecarbil rescues these defects.

Confined magnetotactic bacteria exhibit circling and U-turn trajectories explained by a competition of alignment with a magnetic field and alignment along the confining walls as well as considerable cell-to-cell heterogeneity.