A method of generating comprehensive maps of cochlear cells was created and enabled researchers to study characteristics of cellular damage in aged and noise-exposed inner ear.
Martin L Basch, Rogers M Brown II ... Andrew K Groves
The cochlea deploys two Fringe proteins at exactly the same time and position to regulate a novel mode of Notch signaling that sets the boundary of the organ of Corti, the ear's hearing organ.
Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
A dynamic confrontation between Notch signalling and the transcription factor Lmx1a at the borders of the developing inner ear sensory patches regulates their segregation and the positioning of their boundaries.
Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
Adelaida M Celaya, Isabel Sánchez-Pérez ... Isabel Varela-Nieto
Mitogen-activated protein kinase phosphatase 1 (DUSP1) deficiency causes early redox imbalance and increased inflammatory response in the cochlea, leading to cell loss and progressive neurosensory hearing loss.
Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.