101 results found
    1. Neuroscience

    Cellular cartography of the organ of Corti based on optical tissue clearing and machine learning

    Shinji Urata, Tadatsune Iida ... Shigeo Okabe
    A method of generating comprehensive maps of cochlear cells was created and enabled researchers to study characteristics of cellular damage in aged and noise-exposed inner ear.
    1. Cell Biology
    2. Developmental Biology

    Fine-tuning of Notch signaling sets the boundary of the organ of Corti and establishes sensory cell fates

    Martin L Basch, Rogers M Brown II ... Andrew K Groves
    The cochlea deploys two Fringe proteins at exactly the same time and position to regulate a novel mode of Notch signaling that sets the boundary of the organ of Corti, the ear's hearing organ.
    1. Developmental Biology
    2. Neuroscience

    Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

    Sung-Ho Huh, Mark E Warchol, David M Ornitz
    Otic epithelial Fibroblast Growth Factors control the number of cochlear sensory progenitor cells through an FGF responsive periotic mesenchyme.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Generation of inner ear hair cells by direct lineage conversion of primary somatic cells

    Louise Menendez, Talon Trecek ... Neil Segil
    Direct reprogramming of somatic cells to an inner ear sensory hair cell-like state provides an experimental platform to identify causes and treatments for hair cell loss and hearing deficits.
    1. Developmental Biology

    Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a

    Zoe F Mann, Héctor Gálvez ... Nicolas Daudet
    A dynamic confrontation between Notch signalling and the transcription factor Lmx1a at the borders of the developing inner ear sensory patches regulates their segregation and the positioning of their boundaries.
    1. Developmental Biology

    Dysregulation of sonic hedgehog signaling causes hearing loss in ciliopathy mouse models

    Kyeong-Hye Moon, Ji-Hyun Ma ... Jinwoong Bok
    Developmental defects of the cochlea caused by dysregulation of sonic hedgehog signaling are the potential etiology for hearing loss in a group of ciliopathies with defective ciliogenesis.
    1. Cell Biology
    2. Neuroscience

    Repair of noise-induced damage to stereocilia F-actin cores is facilitated by XIRP2 and its novel mechanosensor domain

    Elizabeth L Wagner, Jun-Sub Im ... Jung-Bum Shin
    A novel mechanism for F-actin repair is involved in the maintenance of sensory hair cells and hearing function.
    1. Neuroscience

    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

    Adelaida M Celaya, Isabel Sánchez-Pérez ... Isabel Varela-Nieto
    Mitogen-activated protein kinase phosphatase 1 (DUSP1) deficiency causes early redox imbalance and increased inflammatory response in the cochlea, leading to cell loss and progressive neurosensory hearing loss.
    1. Cell Biology
    2. Neuroscience

    A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells

    Philippe FY Vincent, Yohan Bouleau ... Didier Dulon
    A synaptic F-actin network tightly controls the flow of synaptic vesicles during exocytosis at the inner hair cell ribbons.
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    1. Neuroscience

    Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae

    Wenxuan He, David Kemp, Tianying Ren
    Heterodyne low-coherence interferometry demonstrates that the latency of the sound-induced reticular lamina vibration is significantly greater than that of the basilar membrane vibration in living gerbil cochleae.

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