Experiments with mammalian cells and Xenopus egg extracts elucidate how three proteins cooperate to shape the reticular endoplasmic reticulum network.

Novel disease pathways underlie disease pathogenesis in Kelch-related nemaline myopathy through proteomic remodeling.

The dual role of Drosophila Mitofusin in steroid hormone production and cholesterol ester storage, which is evolutionary conserved by the combined expression of the two mammalian Mitofusins, ensures proper synaptic development.

Sequential phosphorylation of NDEL1 Ser336/Ser332 by DYRK2 and GSK3β is a novel regulatory step for actin dynamics that contributes to the neurite outgrowth and neuronal arborization in the developing brain.

VPS13A is associated with the endoplasmic reticulum, mitochondria and lipid droplets and is required for cellular processes that require interaction between these organells.

Plasmodium falciparum apicoplast SufS is required for both iron-sulfur synthesis and tRNA modification by MnmA, a novel paradigm that is likely to apply to other plastid-containing organisms.

The mechanism is revealed that connects the protein degradation machinery to cellular membrane-bound compartments during proteostasis stress in mammalian cells.

In central synapses, the mobility and supply of synaptic vesicles are determined by two independent biological factors: the morphological and structural organization of nerve terminals and the molecular signature of vesicles.

BDNF-regulated deployment of Rab10 to the distal axon regulates retrograde propagation of neurotrophic signalling, providing a flexible mechanism to fine-tune the communication between the synapse and the cell body of neurons, as well as novel therapeutic targets for neurodegeneration.