2 results found
    1. Cancer Biology

    Arid1a restrains Kras-dependent changes in acinar cell identity

    Geulah Livshits, Direna Alonso-Curbelo ... Scott W Lowe
    Arid1a loss in the pancreas enables an irreversible reprogramming of cell fate that is dependent on both cellular and genetic context.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Single-PanIN-seq unveils that ARID1A deficiency promotes pancreatic tumorigenesis by attenuating KRAS-induced senescence

    Shou Liu, Wenjian Cao ... Chenghang Zong
    ARID1A deficiency in SWI/SNF complex promotes pancreatic tumor development by upregulating ALDH protein levels to effectively reduce cellular reactive oxygen species levels, leading to the significant attenuation of oncogenic KRAS-induced senescence.

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