1,400 results found
    1. Computational and Systems Biology

    Network design principle for robust oscillatory behaviors with respect to biological noise

    Lingxia Qiao, Zhi-Bo Zhang ... Lei Zhang
    Searching all two- and three-node gene regulatory network topologies identifies the repressilator with positive autoregulation as the motif capable of accurate oscillation and reveals the long period and high amplitude as two distinct mechanisms for buffering different noise.
    1. Evolutionary Biology

    Wings and halteres act as coupled dual oscillators in flies

    Tanvi Deora, Siddharth S Sane, Sanjay P Sane
    Flight system of flies is driven by wings and mechanosensory halteres that operate as independently driven but coupled oscillators, thereby imparting robustness against wing or thorax damage.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

    Alexis B Webb, Iván M Lengyel ... Andrew C Oates
    Time-lapse recording and theoretical analysis of individual cells isolated from the zebrafish segmentation clock reveal that they behave as self-sustained, autonomous oscillators with distinctive noisy dynamics.
    Short Report Updated
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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Rapid cell-free forward engineering of novel genetic ring oscillators

    Henrike Niederholtmeyer, Zachary Z Sun ... Sebastian J Maerkl
    Rapid forward engineering can be accomplished using cell-free systems, as demonstrated by the implementation and characterization of novel genetic oscillators in a cell-free system and their consequent transfer to cells.
    1. Neuroscience

    Peripheral sensory coding through oscillatory synchrony in weakly electric fish

    Christa A Baker, Kevin R Huck, Bruce A Carlson
    Sensory receptors encode stimuli by transiently synchronizing ongoing electrical oscillations, conferring enhanced sensitivity to communication signals produced by large groups of conspecifics.
    1. Computational and Systems Biology
    2. Neuroscience

    Phase response analyses support a relaxation oscillator model of locomotor rhythm generation in Caenorhabditis elegans

    Hongfei Ji, Anthony D Fouad ... Christopher Fang-Yen
    Behavioral, optogenetic, and computational modeling analyses show that the roundworm Caenorhabditis elegans uses a relaxation oscillation mechanism to generate rhythmic locomotor patterns.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Evolving a 24-hr oscillator in budding yeast

    Gregg A Wildenberg, Andrew W Murray
    New complex traits can evolve through the elimination of genes in multiple unrelated pathways, rather than through the creation of new gene functions.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

    Brian Tenner, Michael Getz ... Jin Zhang
    Nanodomain clustering of cAMP effectors represents a novel mechanism of cAMP compartmentation within an oscillatory signaling circuit.
    1. Neuroscience

    Excitatory motor neurons are local oscillators for backward locomotion

    Shangbang Gao, Sihui Asuka Guan ... Mei Zhen
    Motor neurons are rhythm generators for backward locomotion.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    A robust and tunable mitotic oscillator in artificial cells

    Ye Guan, Zhengda Li ... Qiong Yang
    The development of a robust and tunable artificial cell-cycle system paves the way for quantitative characterization of complex clock functions.
    Short Report Updated
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