414 results found
    1. Developmental Biology
    2. Plant Biology

    Generation of shape complexity through tissue conflict resolution

    Alexandra B Rebocho, Paul Southam ... Enrico Coen
    Genetic modulation in patterns of tissue conflict play a major role in the development and evolution of shape diversity.
    1. Developmental Biology

    Visceral organ morphogenesis via calcium-patterned muscle constrictions

    Noah P Mitchell, Dillon J Cislo ... Sebastian J Streichan
    Whole-organ live imaging and computational analysis reveal a calcium-mediated mechanical program linking gene expression to organ shape.
    1. Structural Biology and Molecular Biophysics

    Large-scale state-dependent membrane remodeling by a transporter protein

    Wenchang Zhou, Giacomo Fiorin ... José D Faraldo-Gómez
    The conformational mechanism of a transporter protein is found to have profound and energetically costly effects on the morphology of the surrounding membrane.
    1. Physics of Living Systems

    3D single cell migration driven by temporal correlation between oscillating force dipoles

    Amélie Luise Godeau, Marco Leoni ... Daniel Riveline
    A phase shift between local contractions drives 3D cell motility in experiments and in model or how a finite area in the dipole-quadrupole space explains cell motion with zero total force.
    1. Neuroscience

    Sensitization of meningeal afferents to locomotion-related meningeal deformations in a migraine model

    Andrew S Blaeser, Jun Zhao ... Dan Levy
    Functional imaging of individual sensory afferents that innervate the cranial meninges in a mouse migraine model reveals heightened responsiveness to movement-related meningeal deformations that may underlie headache.
    1. Cell Biology
    2. Physics of Living Systems

    Phagocytic ‘teeth’ and myosin-II ‘jaw’ power target constriction during phagocytosis

    Daan Vorselen, Sarah R Barger ... Mira Krendel
    During ingestion of antibody-coated targets, phagocytes probe and deform the target via Arp2/3-dependent protrusions and myosin-dependent constriction during cup closure.
    1. Structural Biology and Molecular Biophysics

    A modular platform for automated cryo-FIB workflows

    Sven Klumpe, Herman KH Fung ... Julia Mahamid
    SerialFIB is an adaptable open-source software designed for streamlining, advanced development and automation of cryo-focused ion beam-based cellular preparations for in situ cryo-electron tomography.
    1. Structural Biology and Molecular Biophysics

    Piezo’s membrane footprint and its contribution to mechanosensitivity

    Christoph A Haselwandter, Roderick MacKinnon
    Membrane mechanics predict that the ion channel Piezo recruits the surrounding membrane to amplify its sensitivity to changes in membrane tension, with greatest sensitivity in the low-tension regime.
    1. Physics of Living Systems

    Active morphogenesis of patterned epithelial shells

    Diana Khoromskaia, Guillaume Salbreux
    An epithelium modelled as an active, nematic surface can display flattening, budding, and tubulation morphogenetic events, which are observed during development in biological organisms.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Microtubules soften due to cross-sectional flattening

    Edvin Memet, Feodor Hilitski ... L Mahadevan
    A combination of experiments, theory, and simulations shows that the elastic softening of microtubules when they are bent arises due to the flattening of their tubular cross-section.

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