47 results found
    1. Neuroscience

    7-Dehydrocholesterol-derived oxysterols cause neurogenic defects in Smith-Lemli-Opitz syndrome

    Hideaki Tomita, Kelly M Hines ... Libin Xu
    A 7-dehydrocholesterol-derived oxysterol in SLOS was found to profoundly impact neurogenesis during cortical development by interacting with glucocorticoid receptor, which points to new therapeutic approaches for SLOS by targeting the activities of this oxysterol.
    1. Cell Biology

    A concerted mechanism involving ACAT and SREBPs by which oxysterols deplete accessible cholesterol to restrict microbial infection

    David B Heisler, Kristen A Johnson ... Arun Radhakrishnan
    An essential role for ACAT in conferring 25HC-mediated protection against bacterial and viral infection has been uncovered.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

    Sigrid Nachtergaele, Daniel M Whalen ... Rajat Rohatgi
    A cysteine-rich domain within the Smoothened receptor may represent a novel therapeutic target for cancers caused by abnormal functioning of the Hedgehog signaling pathway.
    1. Structural Biology and Molecular Biophysics
    2. Computational and Systems Biology

    Mechanism of allosteric regulation of β2-adrenergic receptor by cholesterol

    Moutusi Manna, Miia Niemelä ... Ilpo Vattulainen
    Atomistic simulations reveal how lipids can allosterically modulate membrane receptors.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

    Tangsheng Yi, Jason G Cyster
    The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.
    1. Cell Biology
    2. Developmental Biology

    Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

    Maia Kinnebrew, Ellen J Iverson ... Rajat Rohatgi
    The patched hedgehog receptor inhibits the transmembrane transducer smoothened by reducing the accessibility of cholesterol locally at the membrane of the primary cilium.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

    Giovanni Luchetti, Ria Sircar ... Rajat Rohatgi
    Cholesterol regulates cell-cell communication by activating the Hedgehog pathway, a central signaling system in development, regeneration and cancer.
    1. Genetics and Genomics

    Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

    Shunxing Rong, Víctor A Cortés ... Jay D Horton
    SREBP-2 directly regulates genes involved in cholesterol homeostasis and indirectly regulates fatty acid synthesis through the production of a ligand responsible for the activation of LXR and SREBP-1c.
    1. Cell Biology

    Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP

    Li Zhang, Prashant Rajbhandari ... Peter Tontonoz
    The E3 ubiquitin ligase RNF145 is shown to contribute to crosstalk between the LXR and SREBP-2 pathways in the regulation of cholesterol homeostasis.

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