506 results found
    1. Genetics and Genomics

    Closely related type II-C Cas9 orthologs recognize diverse PAMs

    Jingjing Wei, Linghui Hou ... Yongming Wang
    Closely related type II-C Cas9 orthologs recognize diverse PAMs, which facilitates us to expand the targeting scope.
    1. Cancer Biology
    2. Cell Biology

    Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells

    Alejandro La Greca, Nicolás Bellora ... Patricia Saragüeta
    Binding of progesterone receptor and transcription factor PAX2 to pre-assembled permissive chromatin compartments regulates endometrial cancer gene expression under estrogenic conditions.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    A FYVE zinc finger domain protein specifically links mRNA transport to endosome trafficking

    Thomas Pohlmann, Sebastian Baumann ... Michael Feldbrügge
    An endosomal component employs a novel PAM2-like motif to recruit a key RNA-binding protein, which explains how mRNAs and associated ribosomes are attached to endosomes during coupled transport.
    1. Immunology and Inflammation

    Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation

    Hyewon Phee, Byron B Au-Yeung ... Arthur Weiss
    The p21-activated kinase 2 (Pak2) is an essential regulator that governs the actin cytoskeleton-dependent signaling to ensure normal thymocyte development, maturation and egress.
    1. Biochemistry and Chemical Biology

    Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation throughout mRNA lifespan with most impact on short tails

    Sandy Mattijssen, James R Iben ... Richard J Maraia
    LARP4 protects mRNAs against deadenylation over a wide range of poly(A) lengths but with most apparent functional impact on short lengths known to sensitize PABP binding and mRNA stability.
    1. Developmental Biology

    Delilah, prospero, and D-Pax2 constitute a gene regulatory network essential for the development of functional proprioceptors

    Adel Avetisyan, Yael Glatt ... Adi Salzberg
    Novel binding sites within a chordotonal-specific enhancer of the delilah gene integrates opposing signals of Prospero and D-Pax2 to control the alternative differentiation programs of cap versus scolopale cells.
    1. Cell Biology
    2. Immunology and Inflammation

    Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses

    Jessica F Walls, Jeff J Subleski ... David K Finlay
    Pharmacological activation of the metabolic activities of PKM2 in murine NK cells disrupts cellular redox balance and inhibits optimal NK cell effector functions.
    1. Neuroscience

    Dietary sugar inhibits satiation by decreasing the central processing of sweet taste

    Christina E May, Julia Rosander ... Monica Dus
    Taste-dependent satiation, which induces proper cessation of feeding in mammals as well as insects, is weakened by sugar-diet-driven taste impairment in the fruit fly.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Conformational fingerprinting of allosteric modulators in metabotropic glutamate receptor 2

    Brandon Wey-Hung Liauw, Arash Foroutan ... Reza Vafabakhsh
    A combination of single-molecule and in vivo FRET showed how drugs affect conformation of mGluR2 at different domains.
    1. Computational and Systems Biology
    2. Structural Biology and Molecular Biophysics

    Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation

    Jamie A Macpherson, Alina Theisen ... Dimitrios Anastasiou
    Specific residues within an enzyme integrate allosteric inputs that originate from distinct ligand-binding pockets.

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