Alejandro La Greca, Nicolás Bellora ... Patricia Saragüeta
Binding of progesterone receptor and transcription factor PAX2 to pre-assembled permissive chromatin compartments regulates endometrial cancer gene expression under estrogenic conditions.
Thomas Pohlmann, Sebastian Baumann ... Michael Feldbrügge
An endosomal component employs a novel PAM2-like motif to recruit a key RNA-binding protein, which explains how mRNAs and associated ribosomes are attached to endosomes during coupled transport.
The p21-activated kinase 2 (Pak2) is an essential regulator that governs the actin cytoskeleton-dependent signaling to ensure normal thymocyte development, maturation and egress.
Sandy Mattijssen, James R Iben ... Richard J Maraia
LARP4 protects mRNAs against deadenylation over a wide range of poly(A) lengths but with most apparent functional impact on short lengths known to sensitize PABP binding and mRNA stability.
Novel binding sites within a chordotonal-specific enhancer of the delilah gene integrates opposing signals of Prospero and D-Pax2 to control the alternative differentiation programs of cap versus scolopale cells.
Jessica F Walls, Jeff J Subleski ... David K Finlay
Pharmacological activation of the metabolic activities of PKM2 in murine NK cells disrupts cellular redox balance and inhibits optimal NK cell effector functions.
Taste-dependent satiation, which induces proper cessation of feeding in mammals as well as insects, is weakened by sugar-diet-driven taste impairment in the fruit fly.