A combined chemical genetics, proximity labeling, and ADP-ribose site mapping approach shows that PARP-7 mono-ADP-ribosylates immune-relevant proteins on cysteine amino acids.

PARP-7 is a mono(ADP-ribosyl) transferase that directs an extensive ADP-ribosylated proteome to control microtubule stability, and regulate ovarian cancer cell growth and motility.

A cryo-electron microscopy study of the human CLC-1 chloride ion channel reveals the structural basis of why some CLC proteins function as passive chloride channels whereas others function as an active proton-chloride antiporters.

A structural and biochemical approach shows that CTP binding and hydrolysis regulate nucleation, spreading, and recycling of a chromosome segregation protein ParB.

A mathematical model for a popular biological diversity mechanism, cyclic dominance, is more likely to emerge by assembly than by evolutionary diversification, which rationalizes why few empirically studies find it.

Outer membrane vesicles serve as decoys to reduce the chance of direct polymyxin B (PMB) binding to cells, which partly explains why many clinical isolates and microbial communities can be protected against PMB treatment.

A set of canonical computational principles implemented in a simple feedforward neural network naturally gives rise to the network's sensitivity to numerosity and its illusory effects, providing an explanation for the ubiquity of the number sense in the animal kingdom.

The structure of the Nef:AP-2 complex has been determined and used as the basis of a model that explains how HIV-1 Nef downregulates the CD4 receptor from the surface of the infected cells.

Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.

Mathematical characterization of the shape of cellular protrusions that form cell–cell contacts in tissues reveals the parameters required for optimizing biological functional objectives, like maximizing cell–cell contact and communicating directional information.