793 results found
    1. Medicine

    Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro

    Giovanni Stefano Ugolini, Andrea Pavesi ... Monica Soncini
    Human cardiac fibroblasts regulate their cellular responses according to the combination of multiple environmental stimuli namely oxygen changes and mechanical signals.
    1. Neuroscience

    Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity

    Hannah L Payne, Ranran L French ... Jennifer L Raymond
    Patterned optogenetic stimulation and analysis of neural activity provide convergent evidence that cerebellar Purkinje cells drive eye movements with a rapid rate code, without an additional contribution of spike irregularity.
    1. Computational and Systems Biology
    2. Neuroscience

    T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells

    Marcel Beining, Lucas Alberto Mongiat ... Peter Jedlicka
    T2N, a novel interface between Matlab, TREES toolbox and NEURON, was used to generate compartmental models that reproduce the electrophysiology of dentate granule cells over a multitude of species, experimental conditions and developmental stages.
    1. Cell Biology

    Activation of transient receptor potential vanilloid 4 is involved in pressure overload-induced cardiac hypertrophy

    Yan Zou, Miaomiao Zhang ... Bing Han
    Activation of TRPV4 induced increases in Ca2+ influx, activated CaMKII, enhanced pro-inflammatory NFκB-NLRP3 signaling, and promoted inflammation response, thus contributing to pathological cardiac remodeling.
    1. Computational and Systems Biology

    Spatial–temporal order–disorder transition in angiogenic NOTCH signaling controls cell fate specification

    Tae-Yun Kang, Federico Bocci ... Andre Levchenko
    The transition from a restrictive patterning mechanism to one sensitive to a variety of environmental cues in NOTCH-mediated angiogenesis offers crucial insights into vascularization in damaged organs and cancer therapy.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Metrics of high cofluctuation and entropy to describe control of cardiac function in the stellate ganglion

    Nil Z Gurel, Koustubh B Sudarshan ... Olujimi A Ajijola
    Networked cardiac control, revealed through analysis of extended baseline-state multi-channel recordings, differentiates heart failure and normal regimes highlighting the promise of peripheral neurally based clinical interventions.
    1. Developmental Biology

    Amino acid transporter SLC38A5 regulates developmental and pathological retinal angiogenesis

    Zhongxiao Wang, Felix Yemanyi ... Jing Chen
    Experimental analysis of SLC38A5 (solute carrier family 38 member 5) in mouse models and cell culture reveals its novel role as a metabolic regulator of retinal angiogenesis by controlling nutrient uptake and homeostasis in blood vessel endothelium.
    1. Medicine

    Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

    Simone Bersini, Roberta Schulte ... Martin W Hetzer
    Direct reprogramming of smooth muscle cells from HGPS patients revealed that BMP4 is a key contributor of vascular degeneration and might represent a new therapeutic target.
    1. Cell Biology
    2. Neuroscience

    Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans

    Jamie L Courtland, Tyler WA Bradshaw ... Scott H Soderling
    Cellular etiology of a human WASH complex mutation in mice reveals its specific roles in neuronal organelle trafficking and a surprising role in motor impairments.
    1. Neuroscience

    Structural and functional properties of a probabilistic model of neuronal connectivity in a simple locomotor network

    Andrea Ferrario, Robert Merrison-Hort ... Roman Borisyuk
    A new probabilistic model of connectivity reveals the structural and functional properties of the neural networks controlling locomotion in many individual tadpoles.

Refine your results by:

Type
Research categories