The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.
Arun Devotta, Hugo Juraver-Geslin ... Jean-Pierre Saint-Jeannet
A combination of morpholino-based knockdowns, pharmacological inhibitors, and rescue assays reveal a novel role for natriuretic peptide signaling in the regulation of cell fates in the embryonic ectoderm.
Julien Gronnier, Christina M Franck ... Cyril Zipfel
The perception of endogenous RALF signaling peptides modulates the plasma membrane nanoscale organization of receptor kinases to regulate plant immune signaling.
B-type natriuretic peptide (BNP) modulates itch via BNP-NPRC pathway by enhancing NMB-NMBR signaling, which is independently of gastrin-releasing peptide (GRP)-GRPR signaling in the spinal cord.
Luis Alfonso Yañez-Guerra, Xingxing Zhong ... Maurice R Elphick
Discovery of a novel neuropeptide signalling system in a deuterostome invertebrate reveals the evolutionary origin of prolactin-releasing peptide and its relationship with neuropeptides in protostome invertebrates.
The stomatal precursor cell uses autocrine peptide-receptor kinase signaling to self-inhibit its differentiation potential in order to ensure proper stomatal development on the plant epidermis.
Bryan A Martinez, Pedro Reis Rodrigues ... Matthew S Gill
A truncated, non-signaling insulin receptor regulates insulin sensitivity in the nematode C. elegans by sequestering insulin peptides and preventing their interaction with full length receptors.