Hysteretic switching between virulence states has been observed in a human pathogen.

In vitro, in vivo and in silico evidence suggests that bacteria exploit intrinsic chromosomal fluctuations to achieve intracellular transport.

The ParABS system positions plasmids precisely within the cell but just below the threshold for oscillatory dynamics.

Novel and common angiogenic mechanisms crucial for fenestrated brain capillary formation have been identified.

An extracellular proteolytic pathway involving the serine protease HtrA1, its inhibitor SerpinE2, and the transmembrane proteoglycan Syndecan-4 control collective migration of neural crest cells in the developing embryo.

Small molecule inhibition of stem cell differentiation in vitro provides novel insight into how DYRK1A loss disrupts human nervous system development.

CTP and centromere-like parS-DNA act synergistically and catalytically to activate ParB, which remains activated after leaving parS to tune ParA–ParB and ParB–ParB interaction dynamics for robust ParABS-mediated F-plasmid DNA segregation.

Unique sequence feature requirements for the plasmid centromere pSM19035-parS for ParA_pSM-ATPase activation byribbon-helix-helix-ParB_pSM, a non-CTPase centromere-binding protein, evince complex interaction gymnastics among the three reaction components necessary for plasmid partition, which is distinct from ParABS-systems involving helix-turn-helix-ParB-CTPases.

Identification of a developmental mechanism critical for the generation of brain vessel heterogeneity.

The basal body of the type-III secretion system of Yersinia enterocolitica within bacterial membranes shows elasticity and is longer than related isolated systems.