302 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synthetic single domain antibodies for the conformational trapping of membrane proteins

    Iwan Zimmermann, Pascal Egloff ... Markus A Seeger
    Synthetic single domain antibody libraries and a binder selection cascade encompassing ribosome and phage display enable the selection of conformation-specific binders against previously intractable membrane proteins within three weeks.
    1. Cell Biology
    2. Immunology and Inflammation

    NaLi-H1: A universal synthetic library of humanized nanobodies providing highly functional antibodies and intrabodies

    Sandrine Moutel, Nicolas Bery ... Franck Perez
    A fully synthetic library of humanized single domain antibodies yields in vitro high affinity antibodies usable in cell biology and translational projects.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Antibodies to repeat-containing antigens in Plasmodium falciparum are exposure-dependent and short-lived in children in natural malaria infections

    Madhura Raghavan, Katrina L Kalantar ... Joseph L DeRisi
    The dominant targets of host immune response to malaria are repeat elements, which are short stretches of amino acids repeated within Plasmodium falciparum proteins, and these are associated with short-lived and exposure-dependent antibody responses.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    A new topology of the HK97-like fold revealed in Bordetella bacteriophage by cryoEM at 3.5 Å resolution

    Xing Zhang, Huatao Guo ... Z Hong Zhou
    Cryo electron microscopy and structure-based mutagenesis reveal that the bacteriophage BPP-1 contains two of the three major recognized viral folds, one of which exhibits a new topology.
    1. Cell Biology

    A bacteriophage tubulin harnesses dynamic instability to center DNA in infected cells

    Marcella L Erb, James A Kraemer ... Joe Pogliano
    A bacteriophage tubulin homolog, PhuZ, forms a structure with the biochemical, structural, and functional properties of a simplified, bipolar spindle.
    1. Medicine
    2. Immunology and Inflammation

    Identification of novel, clinically correlated autoantigens in the monogenic autoimmune syndrome APS1 by proteome-wide PhIP-Seq

    Sara E Vazquez, Elise MN Ferré ... Mark S Anderson
    Humans with mutations in the AIRE gene exhibit common autoantibodies targeting ovarian and intestinal antigens, including intestinal dysfunction-associated antibodies to enteroendocrine transcription factor RFX6.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition

    Yitong Li, Vijaya Kumar Balakrishnan ... Yongna Xing
    The coupling of the enzyme/structure core to different short linear motifs represents a novel mechanism to diversify and expand the function of signaling proteins.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads

    Huy Quoc Nguyen, Jagoree Roy ... Polly Morrell Fordyce
    A novel high-throughput method for measuring many weak protein-peptide affinities simultaneously reveals how calcineurin, a human phosphatase essential for the immune response, recognizes its peptide substrates.
    1. Medicine

    Targeting a cell surface vitamin D receptor on tumor-associated macrophages in triple-negative breast cancer

    Fernanda I Staquicini, Amin Hajitou ... Renata Pasqualini
    A peptide motif targeting tumor-infiltrating macrophage in triple-negative breast cancer delays tumor growth and favors an antitumor immune response.
    1. Evolutionary Biology

    Binding affinity landscapes constrain the evolution of broadly neutralizing anti-influenza antibodies

    Angela M Phillips, Katherine R Lawrence ... Michael M Desai
    CR9114, one of the most broadly neutralizing anti-influenza antibodies characterized to date, acquires affinity to divergent HA subtypes sequentially, due to higher order interactions between the nested sets of mutations required for binding each distinct subtype.

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