278 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phospholipase D activity couples plasma membrane endocytosis with retromer dependent recycling

    Rajan Thakur, Aniruddha Panda ... Padinjat Raghu
    Phosphatidic acid regulates recycling of endocytosed plasma membrane vesicles in polarized cells through a retromer and Arf1 dependent process.
    1. Cell Biology

    Bardet–Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome

    Yan-Xia Liu, Bin Xue ... Zhen-Chuan Fan
    Bardet–Biedl syndrome 3 (BBS3) protein promotes phospholipase D to load onto the BBSome at the ciliary tip for moving out of the cilium via intraflagellar transport.
    1. Microbiology and Infectious Disease

    The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

    Dario Hüsler, Pia Stauffer ... Hubert Hilbi
    Intracellular growth of the bacterial pathogen Legionella pneumophila in the amoeba Dictyostelium discoideum implicates a bacterial fatty acid transporter as well as dynamic interactions of the distinct membrane-bound replication compartment with host cell lipid droplets.
    1. Microbiology and Infectious Disease

    Discovery of coordinately regulated pathways that provide innate protection against interbacterial antagonism

    See-Yeun Ting, Kaitlyn D LaCourse ... Joseph D Mougous
    Pseudomonas aeruginosa defends against interbacterial antagonism through the coordinated expression of previously uncharacterized pathways that grant threat-specific protection.
    1. Neuroscience

    Molecular basis of fatty acid taste in Drosophila

    Ji-Eun Ahn, Yan Chen, Hubert Amrein
    Molecular-genetic, neural imaging and behavioral analyses reveal how Drosophila melanogaster sense fatty acids, important nutrient compounds, through multimeric Ionoptropic Receptors complexes.
    1. Cell Biology

    Counteracting suppression of CFTR and voltage-gated K+ channels by a bacterial pathogenic factor with the natural product tannic acid

    Yajamana Ramu, Yanping Xu ... Zhe Lu
    Tannic acid acts as an ‘antidote’ against the negative effects of a bacterial enzyme, which can both aggravate cystic fibrosis and enable the anthrax bacteria to evade the immune responses elicited by a typical live vaccine.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors

    Nanako Atsumi, Keiko Yasumatsu ... Atsuko Yamashita
    Sweet and umami taste receptors are capable of sensing chloride ions, a component of table salt other than the salty taste-inducing component, sodium ions, and induce preferable taste sensations such as sweet taste.
    1. Neuroscience

    Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling

    E Nicholas Petersen, Mahmud Arif Pavel ... Scott B Hansen
    Cells utilize a membrane-mediated mechanism for mechanosensation, which involves the disruption of lipid rafts and a signal relayed to an ion channel.
    1. Neuroscience

    Identification of a bilirubin receptor that may mediate a component of cholestatic itch

    James Meixiong, Chirag Vasavda ... Xinzhong Dong
    MRGPRX4 is a bilirubin receptor that may be a therapeutic target for patients suffering from cholestatic itch.
    1. Plant Biology

    Phosphatidylcholines from Pieris brassicae eggs activate an immune response in Arabidopsis

    Elia Stahl, Théo Brillatz ... Philippe Reymond
    Plants detect the presence of phospholipids in eggs from a herbivorous insect and trigger innate immunity.

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