113 results found
    1. Cell Biology

    Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

    Meng Zhao, Niels Banhos Danneskiold-Samsøe ... Katrin J Svensson
    The role of Isthmin-1 in muscle function is defined by using phosphoproteomics to identify distinct and overlapping signaling pathways between Isthmin-1 and insulin.
    1. Biochemistry and Chemical Biology

    Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

    Tiantian Wei, Jue Wang ... Xiaoguang Lei
    A potent and selective DYRK2 inhibitor has been developed and used as a chemical tool to reveal eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) and stromal interaction molecule 1 (STIM1) are new substrates for DYRK2.
    1. Computational and Systems Biology

    The genetic and dietary landscape of the muscle insulin signalling network

    Julian van Gerwen, Stewart WC Masson ... David E James
    Genetic background and dietary environment interact to reshape metabolic signalling networks, and the resulting signalling diversity can illuminate regulatory mechanisms of complex traits.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Phosphoproteomics of ATR signaling in mouse testes

    Jennie R Sims, Vitor M Faça ... Marcus B Smolka
    An in-depth map of ATR signaling during mouse meiosis is revealed using a combination of genetic and pharmacological approaches coupled to quantitative mass spectrometry.
    1. Neuroscience

    Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment

    Vasin Dumrongprechachan, Ryan B Salisbury ... Yevgenia Kozorovitskiy
    A Cre-dependent reporter mouse line is generated, validated, and used to map cell-type-specific proteome and phosphoproteome of corticostriatal projections across postnatal development.
    1. Biochemistry and Chemical Biology

    Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

    Vidyasiri Vemulapalli, Lily A Chylek ... Stephen C Blacklow
    Monitoring SHP2 phosphoproteome dynamics identifies new substrate sites and sites protected from dephosphorylation by its SH2 domains, highlighting distinct scaffolding and catalytic activities in effecting a transmembrane signaling response.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

    Martin Steger, Francesca Tonelli ... Matthias Mann
    Discovery of a physiological LRRK2 substrate and a new mechanism of Rab regulation should aid Parkinson’s research and the understanding of Rab function.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Analysis of CDPK1 targets identifies a trafficking adaptor complex that regulates microneme exocytosis in Toxoplasma

    Alex W Chan, Malgorzata Broncel ... Sebastian Lourido
    Comprehensive characterization of kinase-dependent phosphorylation in the human pathogen Toxoplasma gondii identifies a trafficking adaptor complex required for virulence factor secretion and infection.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Temporal and thermal profiling of the Toxoplasma proteome implicates parasite Protein Phosphatase 1 in the regulation of Ca2+-responsive pathways

    Alice L Herneisen, Zhu-Hong Li ... Sebastian Lourido
    Time-resolved phosphoproteomics and thermal proteome profiling reveal the Ca2+-responsive proteome of the model apicomplexan Taxoplasma gondii, identifying PP1 as a Ca2+-responsive enzyme that regulates Ca2+ uptake to promote parasite motility.
    1. Cell Biology

    Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

    S Zachary Swartz, Hieu T Nguyen ... Arminja N Kettenbach
    Time-course phosphoproteomics reveals that selective dephosphorylation is critical for directing the MI/MII transition and that, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.

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