7 results found
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Evolution of substrate specificity in a retained enzyme driven by gene loss

    Ana Lilia Juárez-Vázquez, Janaka N Edirisinghe ... Francisco Barona-Gómez
    An integrated biochemical and evolutionary analysis shows how enzyme specificity evolves after gene loss during genome decay, implicating relaxation of purifying selection as a driving force for functional divergence.
    1. Cancer Biology
    2. Cell Biology

    Metabolic clogging of mannose triggers dNTP loss and genomic instability in human cancer cells

    Yoichiro Harada, Yu Mizote ... Naoyuki Taniguchi
    Proteomic and metabolomic analyses reveal how mannose exerts its anticancer activity.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex

    Andrew Ryan Passer, Shelly Applen Clancey ... Marco A Coelho
    A novel form of self-fertility evolved in Cryptococcus depauperatus, a close relative to the human pathogenic Cryptococcus species, in which sexual development is attained by self-signaling of a cognate pheromone and pheromone-receptor pair.
    1. Genetics and Genomics
    2. Medicine

    Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS

    Elisabet Stener-Victorin, Gustaw Eriksson ... Anna Benrick
    Elevated levels of ectopic fat and a decreased number of oxidative insulin-sensitive type I muscle fibers in skeletal muscle could lead to insulin resistance in women with polycystic ovary syndrome.
    1. Immunology and Inflammation

    HIF1α is required for NK cell metabolic adaptation during virus infection

    Francisco Victorino, Tarin M Bigley ... Wayne M Yokoyama
    During pathogen infection, natural killer cells require hypoxia-inducible factor-1α for optimal metabolism to prevent apoptosis, thereby reducing viral load and protecting against morbidity.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite

    Abhinay Ramaprasad, Paul-Christian Burda ... Michael J Blackman
    The malaria parasite uses an enzyme called GDPD to absorb choline, an important nutrient, from the bloodstream and this is essential for the parasite to survive inside the red blood cell.

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