3,587 results found
    1. Cell Biology

    Ordered dephosphorylation initiated by the selective proteolysis of cyclin B drives mitotic exit

    James Holder, Shabaz Mohammed, Francis A Barr
    Selective APC/C-mediated proteolysis of cyclin B drives progression through the metaphase-anaphase transition whilst wide-spread waves of dephosphorylation co-ordinate the subsequent events of mitotic exit.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel

    Xiaoyi Mo, Peiyuan Pang ... Jing Yao
    Mg2+-dependent JAK1-mediated phosphorylation sensitizes TRPV2 activity and thermo-threshold, which is counterbalanced by PTPN1-mediated dephosphorylation, highlighting a role of phosphorylation homeostasis in setting the basal activity of TRPV2.
    1. Cell Biology

    Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

    S Zachary Swartz, Hieu T Nguyen ... Arminja N Kettenbach
    Time-course phosphoproteomics reveals that selective dephosphorylation is critical for directing the MI/MII transition and that, through its inherent phospho-threonine preference, PP2A-B55 imposes specific phosphoregulated behaviors that distinguish the two meiotic divisions.
    1. Cell Biology
    2. Neuroscience

    A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling

    Chi-Hong Wu, Vedakumar Tatavarty ... Gina G Turrigiano
    Activity-dependent bidirectional changes in phosphorylation of the autism-associated scaffold protein Shank3 are essential for the expression of homeostatic synaptic plasticity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Serine phosphorylation regulates the P-type potassium pump KdpFABC

    Marie E Sweet, Xihui Zhang ... David L Stokes
    Phosphorylation of a highly conserved serine residue is a physiological response of Escerichia coli to environmental potassium levels that inhibits transport by KdpFABC to maintain cellular homeostasis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins

    Anna Caballe, Dawn M Wenzel ... Juan Martin-Serrano
    ULK3 is a kinase in the abscission checkpoint that temporarily inactivates ESCRT-III proteins via phosphorylation, which is required to delay cytokinesis in response to defects in mitosis.
    1. Chromosomes and Gene Expression

    Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response

    Seunghee Oh, Tamaki Suganuma ... Jerry L Workman
    Histone H3T11 phosphorylation regulates chronological lifespan by linking nutritional stress-response signals to chromatin.
    1. Biochemistry and Chemical Biology

    Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner

    Natasja Barki, Laura Jenkins ... Graeme Milligan
    Differential agonist-induced phosphorylation of free fatty acid receptor 2 is shown in different tissues of transgenic mice engineered to express variant forms of the human ortholog of the receptor.
    1. Cancer Biology
    2. Genetics and Genomics

    Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region

    Sandhya Balasubramanian, Matteo Andreani ... Michela Di Virgilio
    Replication stress induces phosphorylation events within RIF1 intrinsically disordered region that are essential for RIF1's role in DNA replication fork protection.
    1. Neuroscience

    Analysis of protein phosphorylation in nerve terminal reveals extensive changes in active zone proteins upon exocytosis

    Mahdokht Kohansal-Nodehi, John JE Chua ... Dominika Czernik
    Global phosphoproteomic analysis in nerve terminal during exocytosis reveals 252 uniquely regulated phosphosites, highlighting complex regulation of active zone proteins at multiple sites and the role of specific kinases/phosphatases.

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