3,132 results found
    1. Microbiology and Infectious Disease

    Gut microbiota density influences host physiology and is shaped by host and microbial factors

    Eduardo J Contijoch, Graham J Britton ... Jeremiah J Faith
    The density of the gut microbiota influences the host immune system and adiposity, and can be therapeutically manipulated.
    1. Neuroscience

    Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

    Anna Castano, Margaux Silvestre ... Alison D Axtman
    Specific inhibition of cyclin-dependent kinase-like 5 (CDKL5), a kinase linked to a severe neurodevelopmental disorder, demonstrates an important role in the regulation of excitatory hippocampal synapses and synaptic plasticity that was not previously appreciated in rodent knock-out models.
    1. Developmental Biology
    2. Neuroscience

    Insights into electrosensory organ development, physiology and evolution from a lateral line-enriched transcriptome

    Melinda S Modrell, Mike Lyne ... Clare VH Baker
    An unbiased transcriptomic approach reveals that developing paddlefish electrosensory organs express genes essential for mechanosensory hair cell development and synaptic transmission, and identifies candidates for mediating electroreceptor development and function.
  1. Science Forum: Sex differences and sex bias in human circadian and sleep physiology research

    Manuel Spitschan, Nayantara Santhi ... Rhiannon White
    Research on human sleep and circadian physiology exhibits a bias towards male subjects, creating a sex data gap which holds potential real-world impact and requires concerted effort to close.
    1. Neuroscience

    Salivary and plasmatic oxytocin are not reliable trait markers of the physiology of the oxytocin system in humans

    Daniel Martins, Anthony S Gabay ... Yannis Paloyelis
    Single measurements of baseline salivary and plasmatic oxytocin are not sufficiently reliable to provide valid trait markers of the physiology of the oxytocin system in humans.
    1. Computational and Systems Biology
    2. Plant Biology

    Computational modeling and quantitative physiology reveal central parameters for brassinosteroid-regulated early cell physiological processes linked to elongation growth of the Arabidopsis root

    Ruth Großeholz, Friederike Wanke ... Klaus Harter
    The recurring application of computational modelling combined with wet lab experiments identify and predict central regulatory parameters and factors for early cell physiological reactions linked to differential brassinosteroid-modified elongation growth in the root tip of Arabidopsis thaliana.
    1. Neuroscience

    Neuronal morphologies built for reliable physiology in a rhythmic motor circuit

    Adriane G Otopalik, Jason Pipkin, Eve Marder
    Neurite geometry enables expansive and highly-branched neuronal structures to operate like single electrical compartments and simple linear integrators.
    1. Neuroscience

    Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

    Mohammad Ali Salehinejad, Elham Ghanavati ... Michael A Nitsche
    The sleep-deprived brain in humans undergoes upscaled intracortical excitability which diminishes induction of LTP-like plasticity via transcranial electrical stimulation while converting the LTD-like to LTP-like plasticity and these physiological changes couple with impaired learning, memory, and attention at behavioral level.
    1. Cell Biology
    2. Neuroscience

    Social communication of predator-induced changes in Drosophila behavior and germ line physiology

    Balint Z Kacsoh, Julianna Bozler ... Giovanni Bosco
    Reproductive behavior is conferred from experienced to naïve Drosophila as a behavioral social strategy allowing naïve groups to anticipate a threat from a predator.
    1. Cell Biology

    Multiplexed mRNA assembly into ribonucleoprotein particles plays an operon-like role in the control of yeast cell physiology

    Rohini R Nair, Dmitry Zabezhinsky ... Jeffrey E Gerst
    Prokaryotes use polycistronic messages for coordinated translation, whereas eukaryotic cells may achieve tunable protein synthesis by packaging monocistronic mRNAs into functional multiplexes via co-transcriptional interallelic coupling and non-canonical histone-H4 functions.

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