Storage of long-term memory in Aplysia does not require stable synapses.

The enzyme PKMzeta is crucial for the maintenance of long-term memories, but a closely related enzyme provides a back-up should PKMzeta fail, thus explaining the controversy over why deleting the gene for PKMzeta may not appear to impair memory.

Local ATP production by the plasma membrane-associated glycolytic enzyme pyruvate kinase is essential for the nutrient-dependent closure of the ATP-sensitive potassium channels that initiate insulin release from pancreatic β-cells.

Due to subunit-exchange, CaMKII can store information at diverse time-scales and might play a central role in the memory maintenance.

A pharmacological approach for the validation of systems genetics data in the context of insulin resistance.

Comparing the white-footed deermouse with mice and rats in an inflammation model reveals a means for the observed infection tolerance in this key animal reservoir for several human diseases.

Intermittent fasting orchestrates molecular shifts, yielding cardiovascular improvements, revealing novel cardioprotective mechanisms, and suggesting innovative pharmacological strategies for cardiovascular disease prevention and treatment.

17α-Estradiol, a life-span extending compound, signals through estrogen receptor α (ERα) in the liver and hypothalamus to elicit health benefits in a sex-specific manner.