756 results found
    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics

    Irene Gallego Romero, Bryan J Pavlovic ... Yoav Gilad
    A panel of chimpanzee induced pluripotent stem cells (iPSCs) will help realise the potential of iPSCs in primate studies, and in combination with genomic technologies, transform studies of comparative evolution.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

    Samuel A Myers, Sailaja Peddada ... Barbara Panning
    A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

    Elias T Friman, Cédric Deluz ... David M Suter
    OCT4 and SOX2 display partially independent activity to regulate chromatin accessibility, and highly dynamic activity of OCT4 is required throughout the cell cycle to maintain pluripotency enhancer accessibility.
    1. Stem Cells and Regenerative Medicine

    TGFβ signalling is required to maintain pluripotency of human naïve pluripotent stem cells

    Anna Osnato, Stephanie Brown ... Peter J Rugg-Gunn
    Identifying the pathways that support human naive-state pluripotent stem cells provides insights into the signalling-based regulation of human pluripotency and enables informed decisions to improve conditions for pluripotent cell culture.
    1. Stem Cells and Regenerative Medicine

    Distinct SoxB1 networks are required for naïve and primed pluripotency

    Andrea Corsinotti, Frederick CK Wong ... Ian Chambers
    Genetic manipulations show that endogenous transcription factors of the SoxB1 class act redundantly to maintain primed pluripotency and reveal differential effects on transitions between pluripotent and differentiation states.
    1. Stem Cells and Regenerative Medicine

    Derivation of trophoblast stem cells from naïve human pluripotent stem cells

    Chen Dong, Mariana Beltcheva ... Thorold W Theunissen
    Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program

    Madara Ratnadiwakara, Stuart K Archer ... Minna-Liisa Anko
    RNA-binding protein SRSF3 mediates critical changes in RNA processing of pluripotency genes, which reveals functional consequences of regulated RNA processing during stem cell self-renewal and early development.
    1. Stem Cells and Regenerative Medicine

    Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

    Sophie M Morgani, Jakob J Metzger ... Anna-Katerina Hadjantonakis
    Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

    Le Xiong, Erik A Tolen ... Hans R Schöler
    Time-resolved multiomics analysis during Oct4 depletion and recovery reveals concentration-dependent activities of Oct4 in controlling enhancer transcription and chromatin accessibility in mouse embryonic stem cells.
    1. Stem Cells and Regenerative Medicine
    2. Chromosomes and Gene Expression

    Mof-associated complexes have overlapping and unique roles in regulating pluripotency in embryonic stem cells and during differentiation

    Sarina Ravens, Marjorie Fournier ... Làszlò Tora
    Two complexes that contain the histone acetyl transferase MOF have distinct regulatory roles in the growth and development of pluripotent embryonic stem cells

Refine your results by:

Type
Research categories