1,570 results found
    1. Physics of Living Systems

    High-molecular-weight polymers from dietary fiber drive aggregation of particulates in the murine small intestine

    Asher Preska Steinberg, Sujit S Datta ... Rustem F Ismagilov
    Polymers from dietary fiber can control the aggregation of particulates in the murine small intestine in a manner qualitatively consistent with depletion interactions.
    1. Neuroscience

    Thalamocortical synapses in the cat visual system in vivo are weak and unreliable

    Madineh Sedigh-Sarvestani, Larry A Palmer, Diego Contreras
    A characterization of LGN-V1 synaptic transmission properties demonstrates thalamocortical synapses in vivo are weak and unreliable, but biologically constrained models show they efficiently drive cortex.
    1. Neuroscience

    The role of higher-order thalamus during learning and correct performance in goal-directed behavior

    Danilo La Terra, Ann-Sofie Bjerre ... Lucy M Palmer
    The higher order thalamus encodes and influences correct action during learning and performance in a sensory-based goal-directed behavior.
    1. Cell Biology
    2. Medicine

    Polymerization of misfolded Z alpha-1 antitrypsin protein lowers CX3CR1 expression in human PBMCs

    Srinu Tumpara, Matthias Ballmaier ... Sabina Janciauskiene
    Finding that circulating Z alpha-1 antitrypsin polymers, a feature of ZZ AAT deficiency, lower the expression of CX3CR1 on peripheral blood mononuclear cells encourages more detailed analyses on different circulating misfolded proteins and their role on immune cell surveillance/function.
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    1. Structural Biology and Molecular Biophysics
    2. Immunology and Inflammation

    The structure and dynamics of secretory component and its interactions with polymeric immunoglobulins

    Beth M Stadtmueller, Kathryn E Huey-Tubman ... Pamela J Bjorkman
    The ectodomain of the human polymeric Ig receptor maintains a closed triangular shape that binds and excludes bacteria in mucosa, or opens to bind and transport polymeric Ig ligands across epithelial cells.
    1. Microbiology and Infectious Disease

    Coordination of peptidoglycan synthesis and outer membrane constriction during Escherichia coli cell division

    Andrew N Gray, Alexander JF Egan ... Waldemar Vollmer
    The protein CpoB regulates PBP1B activity in response to the Tol energy state, which facilitates feedback and synchronicity between envelope constriction processes during Gram-negative bacterial cell division.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth, Kristin L Muench ... Theo D Palmer
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Biochemistry and Chemical Biology

    Real-time monitoring of peptidoglycan synthesis by membrane-reconstituted penicillin-binding proteins

    Víctor M Hernández-Rocamora, Natalia Baranova ... Waldemar Vollmer
    The synthesis of bacterial cell wall peptidoglycan was reconstituted in lipid bilayers and detected by a novel Förster resonance energy transfer real-time assay.
    1. Neuroscience

    Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

    Abigail M Polter, Kelsey Barcomb ... Julie A Kauer
    Rats exposed to a single stressful event experience days-long constitutive activation of the kappa opioid receptor at inhibitory synapses in part of the brain’s reward system, which increases their drug-seeking behavior.
    1. Structural Biology and Molecular Biophysics

    Pathologic polyglutamine aggregation begins with a self-poisoning polymer crystal

    Tej Kandola, Shriram Venkatesan ... Randal Halfmann
    The disease-associated aggregation of polyglutamine begins in a single molecule with a specific structure.

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