1,152 results found
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Science Forum: A low-cost, open-source evolutionary bioreactor and its educational use

    Vishhvaan Gopalakrishnan, Dena Crozier ... Jacob G Scott
    The EVolutionary biorEactor (EVE) can be built for less than $200, and can be used to evaluate microbial population dynamics in the lab and to teach evolution in high schools.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Rapid cell-free forward engineering of novel genetic ring oscillators

    Henrike Niederholtmeyer, Zachary Z Sun ... Sebastian J Maerkl
    Rapid forward engineering can be accomplished using cell-free systems, as demonstrated by the implementation and characterization of novel genetic oscillators in a cell-free system and their consequent transfer to cells.
    1. Ecology
    2. Chromosomes and Gene Expression

    Emerging Technology: Concerning RNA-guided gene drives for the alteration of wild populations

    Kevin M Esvelt, Andrea L Smidler ... George M Church
    Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Repeated origins, widespread gene flow, and allelic interactions of target-site herbicide resistance mutations

    Julia M Kreiner, George Sandler ... Stephen I Wright
    The spread of herbicide resistance in one of the most problematic weeds in North America occurs through both recent, repeated mutational origins and gene flow across an international network of agricultural fields.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Current CRISPR gene drive systems are likely to be highly invasive in wild populations

    Charleston Noble, Ben Adlam ... Martin A Nowak
    If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Reprogramming the antigen specificity of B cells using genome-editing technologies

    James E Voss, Alicia Gonzalez-Martin ... Dennis R Burton
    Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.
    Short Report Updated
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    1. Stem Cells and Regenerative Medicine
    2. Genetics and Genomics

    Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6

    Rasmus O Bak, Daniel P Dever ... Matthew H Porteus
    The CRISPR/Cas9 system can be used with recombinant AAV6 donor delivery to facilitate simultaneous, targeted integration into multiple genetic loci in hematopoietic stem and progrenitor cells.
  1. Meta-Research: Systemic racial disparities in funding rates at the National Science Foundation

    Christine Yifeng Chen, Sara S Kahanamoku ... Justin Hosbey
    White principal investigators applying to the National Science Foundation are consistently funded at higher rates than most non-white PIs.
    1. Medicine

    Point of View: Why both sides of the gender equation matter

    Lindy E Barrett
    It is important that any strategy that seeks to move towards gender parity in science and medicine includes actions to address male advantage and overrepresentation as well as female disadvantage and underrepresentation.
    1. Epidemiology and Global Health
    2. Evolutionary Biology

    COVID-19 CG enables SARS-CoV-2 mutation and lineage tracking by locations and dates of interest

    Albert Tian Chen, Kevin Altschuler ... Benjamin E Deverman
    COVID-19 CG is an open source web resource that allows vaccine, therapeutics, and diagnostics developers to track SARS-CoV-2 mutations and lineages by location and time.

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