Vishhvaan Gopalakrishnan, Dena Crozier ... Jacob G Scott
The EVolutionary biorEactor (EVE) can be built for less than $200, and can be used to evaluate microbial population dynamics in the lab and to teach evolution in high schools.
Henrike Niederholtmeyer, Zachary Z Sun ... Sebastian J Maerkl
Rapid forward engineering can be accomplished using cell-free systems, as demonstrated by the implementation and characterization of novel genetic oscillators in a cell-free system and their consequent transfer to cells.
Kevin M Esvelt, Andrea L Smidler ... George M Church
Combining CRISPR/Cas9 genome editing with gene drives may enable scientists to reversibly edit the genomes of diverse wild populations, an advance that could help eliminate diseases, support sustainable agriculture, and control invasive species.
Julia M Kreiner, George Sandler ... Stephen I Wright
The spread of herbicide resistance in one of the most problematic weeds in North America occurs through both recent, repeated mutational origins and gene flow across an international network of agricultural fields.
If released in the wild, current CRISPR-based gene drive systems designed to alter populations could spread much farther than intended, despite the evolution of drive resistance.
James E Voss, Alicia Gonzalez-Martin ... Dennis R Burton
Antibody paratopes can be added to the human repertoire by CRISPR-Cas9 editing of B lymphocytes using a strategy that allows for hypermutation and class switching of resulting B cell receptors.
Rasmus O Bak, Daniel P Dever ... Matthew H Porteus
The CRISPR/Cas9 system can be used with recombinant AAV6 donor delivery to facilitate simultaneous, targeted integration into multiple genetic loci in hematopoietic stem and progrenitor cells.
It is important that any strategy that seeks to move towards gender parity in science and medicine includes actions to address male advantage and overrepresentation as well as female disadvantage and underrepresentation.
Albert Tian Chen, Kevin Altschuler ... Benjamin E Deverman
COVID-19 CG is an open source web resource that allows vaccine, therapeutics, and diagnostics developers to track SARS-CoV-2 mutations and lineages by location and time.