30 results found
    1. Neuroscience

    Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1

    Vincent Huson, Marieke Meijer ... Lennart Niels Cornelisse
    Modulation of the energy barrier for membrane fusion is a common mechanism by which sensors in the synapse produce supralinear calcium dependence of vesicle release and short-term synaptic potentiation.
    1. Neuroscience

    Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits

    Shreya H Dhume, Steven A Connor ... Tabrez J Siddiqui
    LRRTM1 and LRRTM2 play multifaceted roles in the molecular organization of neuronal circuits through mediating context-dependent functions in synapse development but independent roles in plasticity and cognition.
    1. Neuroscience

    Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses

    Nicholas P Vyleta, Carolina Borges-Merjane, Peter Jonas
    Activity-dependent enhancement of transmitter release makes the hippocampal mossy fiber synapse a full detonator in rats.
    1. Neuroscience

    Potentiation of cerebellar Purkinje cells facilitates whisker reflex adaptation through increased simple spike activity

    Vincenzo Romano, Licia De Propris ... Chris I De Zeeuw
    Physiological and behavioral analyses show that expression of cerebellar whisker learning can be mediated by increased simple spike activity, depending on LTP induction at parallel fiber to Purkinje cell synapses.
    1. Neuroscience
    2. Physics of Living Systems

    A theory of synaptic transmission

    Bin Wang, Olga K Dudko
    The analytic theory establishes the general principles of synaptic transmission, enables extraction of microscopic parameters of synaptic fusion machinery from experiments, and links molecular constituents to synaptic function.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle

    Cameron Hill, Elisabetta Brunello ... Malcolm Irving
    The physiological contraction of skeletal muscle is controlled by structural changes in the thick filaments, establishing a new paradigm for developing potential treatments for muscle weakness.
    1. Neuroscience

    Glutamate is required for depression but not potentiation of long-term presynaptic function

    Zahid Padamsey, Rudi Tong, Nigel Emptage
    Electrophysiological and optical analysis of neurotransmitter release at central synapses reveals that glutamate signalling is not required for the long-term potentiation (LTP) of presynaptic function, and instead only promotes presynaptic long-term depression (LTD).
    1. Neuroscience

    Non-Hebbian plasticity transforms transient experiences into lasting memories

    Islam Faress, Valentina Khalil ... Sadegh Nabavi
    1. Neuroscience

    Homeostatic regulation of perisynaptic matrix metalloproteinase 9 (MMP9) activity in the amblyopic visual cortex

    Sachiko Murase, Dan Winkowski ... Elizabeth M Quinlan
    Dark exposure lowers the MMP9 activation threshold, and subsequent light stimulation to an amblyopic eye is sufficient to induce proteolysis at thalamo-cortical synapses in deprived mouse visual cortex.
    1. Cell Biology
    2. Neuroscience

    Mitochondrial support of persistent presynaptic vesicle mobilization with age-dependent synaptic growth after LTP

    Heather L Smith, Jennifer N Bourne ... Kristen M Harris
    Three-dimensional electron microscopy (3DEM) demonstrates the dependence on presynaptic mitochondria for vesicle mobilization as dendritic spines are silently added at P15 or synapses are silently enlarged in adults after long-term potentiation.

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