25 results found
    1. Plant Biology

    Arabidopsis plants perform arithmetic division to prevent starvation at night

    Antonio Scialdone, Sam T Mugford ... Martin Howard
    Plants implement arithmetic division to optimize use of carbohydrate reserves and thus maintain metabolism and growth at night.
    1. Microbiology and Infectious Disease

    Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages

    Florence Caro, Vida Ahyong ... Joseph L DeRisi
    Ribosome profiling has bridged the knowledge gap between transcription and translation during malaria blood stage development and provided a comprehensive gene expression resource for this parasite.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

    Qi Yang, Thomas A Hughes ... Sriram Neelamegham
    A critical role for glycosylation on viral entry and methods to use this knowledge to reduce SARS-CoV-2 infectivity has been demonstrated.
    1. Cell Biology
    2. Genetics and Genomics

    ReporterSeq reveals genome-wide dynamic modulators of the heat shock response across diverse stressors

    Brian D Alford, Eduardo Tassoni-Tsuchida ... Onn Brandman
    A pooled genetic screening method measures the effect of knocking down every gene on a transcriptional stress response to proteotoxic stress (the heat shock response) using only nucleic acid sequencing, without cell enrichment or single-cell isolation.
    1. Ecology
    2. Neuroscience

    Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase

    Sven Schenk, Stephanie C Bannister ... Kristin Tessmar-Raible
    A molecular profiling approach to quantify transcripts and proteins from identical samples allows study of molecular effects of maturation, sexual differentiation and the endogenous circalunar clock in a marine worm.
    1. Computational and Systems Biology

    Transformer-based deep learning for predicting protein properties in the life sciences

    Abel Chandra, Laura Tünnermann ... Regina Gratz
    The recent developments in large-scale machine learning, especially with the recent Transformer models, display much potential for solving computational problems within protein biology and outcompete traditional computational methods in many recent studies and benchmarks.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes

    Steffen Preissler, Claudia Rato ... David Ron
    Regulation of the endoplasmic reticulum chaperone BiP by calcium.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Importin-β modulates the permeability of the nuclear pore complex in a Ran-dependent manner

    Alan R Lowe, Jeffrey H Tang ... Jan T Liphardt
    The Ran GTPase plays a role in defining the physical properties of the nuclear pore complex transport channel by remodeling the binding interactions of importin-β with the nucleoporin Nup153 at the nuclear face of the pore.
    1. Neuroscience

    Human Neocortical Neurosolver (HNN), a new software tool for interpreting the cellular and network origin of human MEG/EEG data

    Samuel A Neymotin, Dylan S Daniels ... Stephanie R Jones
    Human Neocortical Neurosolver is a new user-friendly software tool for researchers to develop and test hypotheses on cellular/circuit origins of human MEG/EEG signals using a biophysical model.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence

    Christina FS Mages, Axel Wintsche ... Gerd A Müller
    Lin37 is essential for cell-cycle gene repression by the DREAM complex in cellular quiescence and a combined loss of Lin37 and Rb prevents cell-cycle exit in response to growth-limiting signals.

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