1,841 results found
    1. Cell Biology
    2. Neuroscience

    Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3'-end processing

    Piergiorgio La Rosa, Pamela Bielli ... Claudio Sette
    The RNA binding protein Sam68 links a key metabolic route to the neural stem cell fate in the developing mouse brain.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

    Ilaria Pettinati, Pawel Grzechnik ... Christopher J Schofield
    MBLAC1 is an endoribonuclease specific for replication dependent histone pre-mRNA processing during S-phase and may represent a new type of cancer target.
    1. Chromosomes and Gene Expression

    Kinetic competition during the transcription cycle results in stochastic RNA processing

    Antoine Coulon, Matthew L Ferguson ... Daniel R Larson
    Real-time single-molecule visualization of transcription and splicing in living cells reveals that RNA synthesis and processing can occur through multiple pathways on the same gene.
    1. Microbiology and Infectious Disease

    A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

    Dayana C Farhat, Matthew W Bowler ... Christopher Swale
    The epitranscriptomic-driven mRNA polyadenylation pathway protects transcriptome integrity by restricting transcriptional read-throughs and RNA chimera formation in apicomplexan parasites and plants.
    1. Chromosomes and Gene Expression
    2. Plant Biology

    Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes

    Corinna Speth, Emese Xochitl Szabo ... Sascha Laubinger
    Arabidopsis RNA processing factor SERRATE associates with the chromatin of intronless genes, which are usually expressed at low levels, to enhance polymerase II association.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3′ end biogenesis

    Lena Maria Muckenfuss, Anabel Carmen Migenda Herranz ... Martin Jinek
    Molecular details of the interactions of human Fip1 with CPSF30 and CstF77 unravel key aspects of mRNA polyadenylation and its regulation.
    1. Chromosomes and Gene Expression

    SAM homeostasis is regulated by CFIm-mediated splicing of MAT2A

    Anna M Scarborough, Juliana N Flaherty ... Nicholas K Conrad
    The 3'-end formation complex CFIm regulates S-adenosylmethionine (SAM) homeostasis by promoting the splicing of the SAM synthetase transcript, MAT2A.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Synergistic assembly of human pre-spliceosomes across introns and exons

    Joerg E Braun, Larry J Friedman ... Melissa J Moore
    Viewing the dynamic interactions of individual spliceosomal subcomplexes with single pre-messenger RNA molecules reveals how nearby flanking splice sites accelerate pre-spliceosome assembly and the splicing of multi-intron pre-mRNAs.
    1. Chromosomes and Gene Expression

    An mRNA-binding channel in the ES6S region of the translation 48S-PIC promotes RNA unwinding and scanning

    Irene Díaz-López, René Toribio ... Iván Ventoso
    The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
    1. Chromosomes and Gene Expression

    RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit

    Laura Milligan, Camille Sayou ... David Tollervey
    Ubiquitination close to the active site of RNAPII occurs in response to RNA processing events and is linked to transcriptional pausing, which is released following Bre5-Ubp3 mediated deubiquitination associated with the nascent transcript.

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