Presynaptic plasticity in simulated neural networks with a simple biologically plausible learning rule improves metabolic efficiency and lifelong learning capabilities.

Experience alters neurotransmitter release from different axonal compartments in different ways, allowing a set of neurons to coherently modulate behavior through diverse actions on multiple downstream circuits.

An antagonism between Spinophilin and Syd-1 converge on presynaptic actin to control presynaptic plasticity and memory consolidation in the Drosophila mushroom body.

Forward genetic screens define a novel genetic landscape by which diverse, unrelated autism risk genes may converge to commonly affect the robustness of synaptic transmission.

Genetic and electrophysiology experiments provide the first direct evidence that protein kinase C is a calcium-sensing protein in post-tetanic potentiation, a form of synaptic plasticity that supports short-term memory.

Synaptic silencing-induced homeostatic enhancement of presynaptic glutamate release is mediated by the postsynaptic retinoic acid-dependent brain-derived neurotrophic factor (BDNF) synthesis from dendritically targeted BDNF transcripts, leading to retrograde activation of presynaptic tropomyosin receptor kinase B receptors.

Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

The crystal structure of a large C-terminal fragment of Munc13-1 provides a key framework to understand how Munc13-1 mediates neurotransmitter release and presynaptic plasticity.

A screen encompassing all kinases and phosphatases reveals that PI3K-cII, PI3K-cIII and Rab11-dependent recycling endosomes comprise a novel, postsynaptic 'signaling controller' that is part of an integrated, trans-synaptic signaling system necessary for presynaptic homeostatic plasticity.

Genetic and electrophysiological experiments define how homeostatic signaling stabilizes both the gain and short-term dynamic properties of neurotransmitter release, ensuring that synaptic information transfer remains robust to external perturbation.