Alexandre A Germanos, Sonali Arora ... Andrew C Hsieh
A large-scale single-cell RNA sequencing experiment explores single-cell dynamics in epithelial and immune populations within murine prostates upon cancer initiation and progression and validates key findings across orthogonal models and patient specimens.
Joanna L Gillis, Josephine A Hinneh ... Lisa M Butler
A positive feedback loop between the androgen receptor and a key pentose phosphate pathway enzyme, 6PGD, in prostate cancer promotes tumour cell proliferation, survival and intracellular redox control.
Ricardo A Cordova, Jagannath Misra ... Kirk A Staschke
The ISR kinase GCN2 is critical for maintaining tumor amino acid levels to facilitate growth, suggesting a novel therapeutic strategy for the treatment of prostate cancer by inducing starvation for essential amino acids.
Diagnosing the presence and clinical significance of prostate cancer can be achieved using AI-based analysis of peripheral blood natural killer (NK) cell subset profiles.
Depletion of PHF19 in prostate cancer cells leads to an increase in MTF2 and PRC2 chromatin occupancy causing deregulation of key genes critical for proliferation and metastasis.
Epigenetic regulation of the glucocorticoid receptor in castration-resistant prostate cancer can be targeted via the use of BET bromodomain inhibitors.