10,213 results found
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Uncovering the basis of protein-protein interaction specificity with a combinatorially complete library

    Thuy-Lan V Lite, Robert A Grant ... Michael T Laub
    A generalizable approach to understanding the logic of molecular recognition reveals the contributions of individual residues to the specificity of protein-protein interactions.
    1. Microbiology and Infectious Disease

    Distinct regions of H. pylori’s bactofilin CcmA regulate protein–protein interactions to control helical cell shape

    Sophie R Sichel, Benjamin P Bratton, Nina R Salama
    The helical cell shape of Helicobacter pylori depends on the polymerizing cytoskeletal protein CcmA’s recruitment to the cell envelope by Csd5 and CcmA’s indirect stabilization of a periplasmic cell wall hydrolase via interactions with the transmembrane protein Csd7.
    1. Structural Biology and Molecular Biophysics

    Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states

    Dan Tan, Qiang Li ... Xiaoguang Lei
    An enrichable cross-linker with optional isotope labeling quadruples the number of cross-linked peptides identified from high-complexity samples, enhancing proteome-wide analysis of protein-protein interactions and protein conformational changes by mass spectrometry.
    1. Cell Biology

    Synthetic protein interactions reveal a functional map of the cell

    Lisa K Berry, Guðjón Ólafsson ... Peter H Thorpe
    Forcing protein associations across the proteome reveals the cell's tolerance for diverse protein interactions and reveals the interactions that affect growth.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Protein-mediated RNA folding governs sequence-specific interactions between rotavirus genome segments

    Alexander Borodavka, Eric C Dykeman ... Don C Lamb
    In rotaviruses, the selective packaging of eleven distinct genomic RNA segments requires virus-encoded protein NSP2 to alter the RNA structures, facilitating their interactions with each other.
    1. Biochemistry and Chemical Biology

    Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions

    Xi Peng, Francesco Emiliani ... Jeremy Nathans
    Affinity capture of polyribosomes followed by RNAseq(ACAPSeq) is a technique that harnesses massively parallel sequencing to identify protein-protein interactions from any source from which polyribosomes can be purified.
    1. Structural Biology and Molecular Biophysics

    Contacts-based prediction of binding affinity in protein–protein complexes

    Anna Vangone, Alexandre MJJ Bonvin
    The number of contacts at the interface of a protein–protein complex, together with the properties of the surface, provides a simple, but well-performing predictor of binding affinity.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Coevolution-based inference of amino acid interactions underlying protein function

    Victor H Salinas, Rama Ranganathan
    A deep mutational coupling study demonstrates the ability of sequence coevolution methods to reveal the pattern of amino acid interactions underlying protein function.
    1. Biochemistry and Chemical Biology
    2. Stem Cells and Regenerative Medicine

    SOX2 O-GlcNAcylation alters its protein-protein interactions and genomic occupancy to modulate gene expression in pluripotent cells

    Samuel A Myers, Sailaja Peddada ... Barbara Panning
    A post-translational modification called O-GlcNAcylation modulates the activity of the SOX2 transcription factor in pluripotent stem cells.
    1. Genetics and Genomics
    2. Neuroscience

    Homeodomain-interacting protein kinase maintains neuronal homeostasis during normal Caenorhabditis elegans aging and systemically regulates longevity from serotonergic and GABAergic neurons

    Maria I Lazaro-Pena, Adam B Cornwell ... Andrew V Samuelson
    The transcriptional cofactor HPK-1 (homeodomain-interacting protein kinase) functions as a key regulator of multiple proteostatic stress responses, each originating from discrete neuronal subtypes within the Caenorhabditis elegans nervous system to preserve neuronal health and maintain organismal proteostasis during normal aging.

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