2,420 results found
    1. Cell Biology
    2. Microbiology and Infectious Disease

    EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus

    Parikshit Bagchi, Takamasa Inoue, Billy Tsai
    Biochemical and cell-based analyses reveal how a non-enveloped virus exploits the chaperone activity of an ER transmembrane protein to penetrate the ER membrane required for successful virus infection.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Measuring protein stability in the GroEL chaperonin cage reveals massive destabilization

    Ilia Korobko, Hisham Mazal ... Amnon Horovitz
    Protein stability in the cage formed by the chaperonin GroEL and its cofactor GroES is reduced by more than 5 kcal mol-1 relative to that in bulk solution.
    1. Neuroscience

    Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

    Naoto Hayasaka, Arisa Hirano ... Yoshitaka Fukada
    Salt-inducible kinase 3 (SIK3) is an essential component of the mammalian circadian clock machinery, which governs robust circadian behavioral and other rhythms by destabilization of a core clock protein PER2 in a phosphorylation-dependent manner.
    1. Cell Biology

    KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination

    Andres Ramirez-Martinez, Bercin Kutluk Cenik ... Eric N Olson
    KLHL41 acts as a poly-ubiquitin dependent chaperone that prevents the formation of pathogenic nebulin aggregates associated with muscle disease.
    1. Neuroscience

    Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate

    Adam R Almeida, Wendy B Macklin
    Oligodendrocytes iteratively wrap and unwrap the same domain of an axon multiple times during development, which likely impacts myelin sheath stabilization.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics

    Sean M Braet, Theresa SC Buckley ... Ganesh S Anand
    Structural mass spectrometry reveals conformational changes in emerging SARS-CoV-2 spike protein variants that correlate with increased viral fitness.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte, Huange Wang ... Berthold Göttgens
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.
    1. Cell Biology

    Spatial organization shapes the turnover of a bacterial transcriptome

    Jeffrey R Moffitt, Shristi Pandey ... Xiaowei Zhuang
    Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the post-transcriptional fate of bacterial mRNAs.
    1. Developmental Biology

    Regulation of the Drosophila ID protein Extra macrochaetae by proneural dimerization partners

    Ke Li, Nicholas E Baker
    Developmental genetic and cell culture studies indicate that the Inhibitor of DNA-binding protein Extra macrochaetae (Emc), previously thought to determine where bHLH proteins can act, is itself regulated by those bHLH dimerization partners at the level of protein stability.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mutations in SKI in Shprintzen–Goldberg syndrome lead to attenuated TGF-β responses through SKI stabilization

    Ilaria Gori, Roger George ... Caroline S Hill
    The mechanism underlying Shprintzen–Goldberg syndrome is solved and reveals that missense mutations in the transcriptional repressor SKI abolish ligand-induced SKI degradation, which results in attenuation of TGF-β transcriptional responses.

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