474 results found
    1. Evolutionary Biology

    Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information

    Sergey Ovchinnikov, Hetunandan Kamisetty, David Baker
    Co-evolving residue pairs in the different components of a protein complex almost always make contact across the protein–protein interface, thus providing powerful restraints for the modeling of protein complexes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    On the limits of fitting complex models of population history to f-statistics

    Robert Maier, Pavel Flegontov ... David Reich
    Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
    1. Structural Biology and Molecular Biophysics

    A Bayesian approach to single-particle electron cryo-tomography in RELION-4.0

    Jasenko Zivanov, Joaquín Otón ... Sjors HW Scheres
    New functionality in RELION-4.0 allows convenient structure determination from cryo electron tomography data to resolutions sufficient for de novo atomic modelling.
    1. Neuroscience

    An oscillating computational model can track pseudo-rhythmic speech by using linguistic predictions

    Sanne ten Oever, Andrea E Martin
    An oscillating computational model combined with a predictive internal linguistic model can track naturally timed speech in which pseudo-rhythmicity is related to the predictability of words within their sentence context.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The genomic footprint of social stratification in admixing American populations

    Alex Mas-Sandoval, Sara Mathieson, Matteo Fumagalli
    Social hierarchies resulting from the European colonization of the Americas stratified the population structure, leading to ancestry-related assortative mating and sex bias patterns that can be inferred from the genomes of the populations across the continent.
    1. Neuroscience

    Neural dynamics of causal inference in the macaque frontoparietal circuit

    Guangyao Qi, Wen Fang ... Liping Wang
    In causal inference, the premotor cortex dynamically integrates prior information and current sensory inputs to infer hidden structures, and selectively updates sensory representations in the parietal cortex to support behavior.
    1. Neuroscience

    A Bayesian model of context-sensitive value attribution

    Francesco Rigoli, Karl J Friston ... Raymond J Dolan
    The dependence of incentive value attribution on the anticipation of rewards within a given context is explained via a normative Bayesian account of how rewards map to incentive values.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Learning protein constitutive motifs from sequence data

    Jérôme Tubiana, Simona Cocco, Rémi Monasson
    A new machine-learning toolbox unveils coevolutionary protein motifs related to structure, function, and phylogeny from sequence information only.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    Improving statistical power in severe malaria genetic association studies by augmenting phenotypic precision

    James A Watson, Carolyne M Ndila ... Nicholas J White
    Complete blood count data can increase the accuracy of the diagnosis of severe malaria in children in high transmission settings.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Ras-like domain in the light intermediate chain bridges the dynein motor to a cargo-binding region

    Courtney M Schroeder, Jonathan ML Ostrem ... Ronald D Vale
    The dynein light intermediate chain is a member of the G protein superfamily and links the motor to several intracellular cargo adaptors.

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