Johann Holzmann, Antonio Z Politi ... Jan-Michael Peters
Absolute quantification of cohesin, CTCF, NIPBL, WAPL and sororin in HeLa cells implies that some genomic cohesin and CTCF enrichment sites are unoccupied at any one time.
Dynamic interactions of core clock molecules are quantitively measured and mathematically modelled to reveal the hidden role of PER:CRY complexes in enhancing the mobility of CLOCK:BMAL1 to move to new DNA sites.
Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
Neus Martínez-Abadías, Roger Mateu Estivill ... James Sharpe
Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
Pierre Barbier de Reuille, Anne-Lise Routier-Kierzkowska ... Richard S Smith
MorphoGraphX summarizes full 3D datasets as curved surface images (2.5D), enabling the efficient quantification of growth and gene expression data from large time-lapse volumetric datasets.
Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.
The nutrients available in some tumors and the factors that influence tumor nutrient availability are characterized, which provides insight into the metabolic constraints of the tumor microenvironment.
Amanda J Lea, Christopher M Vockley ... Jenny Tung
mSTARR-seq identifies regions of the genome where DNA methylation causally impacts gene expression, providing a map of which epigenetic marks may influence trait variation.
The number of sporozoites expelled by mosquitoes that are infected with lab-cultured or naturally circulating Plasmodium falciparum gametocytes is heterogeneous and associated with the sporozoite load in their salivary glands.