7,892 results found
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Absolute quantification of cohesin, CTCF and their regulators in human cells

    Johann Holzmann, Antonio Z Politi ... Jan-Michael Peters
    Absolute quantification of cohesin, CTCF, NIPBL, WAPL and sororin in HeLa cells implies that some genomic cohesin and CTCF enrichment sites are unoccupied at any one time.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

    Alex A Koch, James S Bagnall ... Andrew SI Loudon
    Dynamic interactions of core clock molecules are quantitively measured and mathematically modelled to reveal the hidden role of PER:CRY complexes in enhancing the mobility of CLOCK:BMAL1 to move to new DNA sites.
    1. Genetics and Genomics

    Simultaneous quantification of mRNA and protein in single cells reveals post-transcriptional effects of genetic variation

    Christian Brion, Sheila M Lutz, Frank Wolfgang Albert
    A CRISPR-based dual reporter assay enables genetic mapping of DNA variants that specifically affect mRNA or protein levels in trans.
    1. Immunology and Inflammation

    Intravital quantification reveals dynamic calcium concentration changes across B cell differentiation stages

    Carolin Ulbricht, Ruth Leben ... Anja E Hauser
    Heterogeneity in cytoplasmic calcium concentration alongside B cell activation and differentiation is measured intravitally using an interdisciplinary imaging approach and novel numerical analysis.
    1. Developmental Biology

    Quantification of gene expression patterns to reveal the origins of abnormal morphogenesis

    Neus Martínez-Abadías, Roger Mateu Estivill ... James Sharpe
    Quantitative analyses associating the morphology of developing organs with dynamic gene expression patterns can reveal biological phenomena that cause malformations and malfunction but remain elusive to traditional qualitative assessments.
    1. Computational and Systems Biology
    2. Developmental Biology

    MorphoGraphX: A platform for quantifying morphogenesis in 4D

    Pierre Barbier de Reuille, Anne-Lise Routier-Kierzkowska ... Richard S Smith
    MorphoGraphX summarizes full 3D datasets as curved surface images (2.5D), enabling the efficient quantification of growth and gene expression data from large time-lapse volumetric datasets.
    1. Neuroscience

    Noninvasive quantification of axon radii using diffusion MRI

    Jelle Veraart, Daniel Nunes ... Noam Shemesh
    Cell-specific architectural properties such as the axon diameter of the white matter of the human brain can be quantified accurately and non-invasively using diffusion magnetic resonance imaging.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

    Mark R Sullivan, Laura V Danai ... Alexander Muir
    The nutrients available in some tumors and the factors that influence tumor nutrient availability are characterized, which provides insight into the metabolic constraints of the tumor microenvironment.
    1. Genetics and Genomics

    Genome-wide quantification of the effects of DNA methylation on human gene regulation

    Amanda J Lea, Christopher M Vockley ... Jenny Tung
    mSTARR-seq identifies regions of the genome where DNA methylation causally impacts gene expression, providing a map of which epigenetic marks may influence trait variation.
    1. Microbiology and Infectious Disease

    Quantification of sporozoite expelling by Anopheles mosquitoes infected with laboratory and naturally circulating P. falciparum gametocytes

    Chiara Andolina, Wouter Graumans ... Teun Bousema
    The number of sporozoites expelled by mosquitoes that are infected with lab-cultured or naturally circulating Plasmodium falciparum gametocytes is heterogeneous and associated with the sporozoite load in their salivary glands.

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