Amrita Rai, Anastasia Oprisko ... Matthias P Müller
A human three-helix Rab-binding domain can potentially bind to two Rab proteins simultaneously with different affinities at binding sites generated by gene duplication.
Snout-to-snout contact modulates the response of rat auditory cortex to calls from other animals, indicating that the multisensory nature of social interaction is directly represented in the rat brain.
Lianna W Wat, Zahid S Chowdhury ... Elizabeth J Rideout
Drosophila females store more fat than males because the presence of a functional Transformer protein in females limits adipokinetic hormone production and pathway activity.
Electrophysiological recordings and a large-scale biophysical model show that a unique inhibitory neuron plays a central role in structuring olfactory codes in the insect brain.
Rachel A Johnston, Philippe Vullioud ... Jenny Tung
In cooperatively breeding Damaraland mole-rats, transitioning to 'queen' results in extensive gene regulatory and morphological remodeling, but also costs to skeletal integrity that scale with reproductive investment.
TET methylcytosine oxidases cooperate with B lineage-specific transcription factors to promote immunoglobulin gene rearrangement by depositing 5hmC, facilitating DNA demethylation and increasing chromatin accessibility at enhancers.
Genetic variations that underlie common autoimmune disease genes are predominantly regulatory and modify the expression of multiple genes within the HLA gene complex and throughout the immune system.
Mukulika Ray, Ashley Mae Conard ... Erica Larschan
Combining computational and experimental approaches reveals that the loss of a maternal transcription factor influences sex-biased differential splicing in the early zygotic transcriptome at genes that are critical for normal developmental processes.