Opioids stop breathing during overdose by silencing two small brain sites, with just 140 neurons in the breathing rhythm generator exerting the key effect.
Julie L Aspden, Ying Chen Eyre-Walker ... Juan-Pablo Couso
Thousands of small Open Reading Frames are translated, and form two distinct classes based on their translational efficiency and bioinformatic indicators.
Advanced models of diffusion-weighted imaging data reveal that intra-axonal volume, especially in left temporoparietal and cerebellar white matter, relates to reading skills in a dataset of 983 children and adolescents.
A control system model of cerebellar patients' movements provides insight into the cerebellum's role in reaching and informs a virtual reality intervention to improve patient reaches.
Stella Reichling, Peter F Doubleday ... Duncan Holbrook-Smith
High throughput metabolome profiling of yeast cells that are dynamically perturbed with the drug rapamycin can be used to implicate new genes in the key cellular process of TOR signaling, including the gene of unknown function CFF1.
Meichao Zhang, Boris C Bernhardt ... Elizabeth Jefferies
Functional neuroimaging in the human brain reveals the neurocognitive mechanisms that underpin the experience of mind-wandering during reading, explaining why comprehension is impaired.
Colin M Cleary, Brenda M Milla ... Daniel K Mulkey
Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.