1,187 results found
    1. Computational and Systems Biology
    2. Developmental Biology

    High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals

    Luciano Marcon, Xavier Diego ... Patrick Müller
    Realistic reaction-diffusion signaling networks that include cell-autonomous factors can robustly form self-organizing spatial patterns for any combination of diffusion coefficients without requiring differential diffusivity.
    1. Neuroscience

    Synaptic input sequence discrimination on behavioral timescales mediated by reaction-diffusion chemistry in dendrites

    Upinder Singh Bhalla
    The powerful computational operation of sequence recognition on behavioral timescales of approximately 1 s may emerge from synaptic activity-triggered build-up of biochemical waves in short 20 micron zones on dendrites.
    1. Computational and Systems Biology
    2. Neuroscience

    Subunit exchange enhances information retention by CaMKII in dendritic spines

    Dilawar Singh, Upinder Singh Bhalla
    Due to subunit-exchange, CaMKII can store information at diverse time-scales and might play a central role in the memory maintenance.
    1. Developmental Biology
    2. Physics of Living Systems

    The proneural wave in the Drosophila optic lobe is driven by an excitable reaction-diffusion mechanism

    David J Jörg, Elizabeth E Caygill ... Benjamin D Simons
    A model of signalling pathways interacting with proneural gene expression explains the sequential patterning of the largest visual processing centre in the developing Drosophila brain.
    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen, Robert N Kelsh, Christian A Yates
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Neuroscience

    Optimal multisensory decision-making in a reaction-time task

    Jan Drugowitsch, Gregory C DeAngelis ... Alexandre Pouget
    Through a combination of modeling and experiments it is shown that humans can near-optimally accumulate decision-related evidence across time and cues even when reaction time is under their control.
    1. Physics of Living Systems

    Plasticity of cell migration resulting from mechanochemical coupling

    Yuansheng Cao, Elisabeth Ghabache, Wouter-Jan Rappel
    Computational and experimental studies show that different migration modes of eukaryotic cells are the result of the interplay between signaling waves and cell mechanics.
    1. Physics of Living Systems

    Mapping out Min protein patterns in fully confined fluidic chambers

    Yaron Caspi, Cees Dekker
    The geometry selection rules of dynamic Min protein patterns are determined in fully confined fluidic chambers, showing that both oscillations and running waves are derivatives of spiral rotations that are established as the majority pattern.
    1. Physics of Living Systems

    Cell-sized confinement controls generation and stability of a protein wave for spatiotemporal regulation in cells

    Shunshi Kohyama, Natsuhiko Yoshinaga ... Nobuhide Doi
    A cell-sized fully confined space significantly controls the emergence and stability of a protein wave, resulting in intracellular spatiotemporal regulation driven by a reaction-diffusion mechanism.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamics of BMP signaling and distribution during zebrafish dorsal-ventral patterning

    Autumn P Pomreinke, Gary H Soh ... Patrick Müller
    Patterning of the dorsal-ventral axis in zebrafish is mediated by a graded source-sink mechanism in which diffusing BMP, produced from a ventrally biased source, is inhibited by dorsally-produced chordin.

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