4,337 results found
    1. Neuroscience

    Efficient recognition of facial expressions does not require motor simulation

    Gilles Vannuscorps, Michael Andres, Alfonso Caramazza
    It is possible to account for efficient facial expression recognition without having to invoke a mechanism of motor simulation, even in very sensitive and challenging tasks.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

    Franziska Bleichert, Maxim Balasov ... James M Berger
    Electron microscopy uncovers the structure of the origin recognition complex (ORC) in metazoans, and reveals how mutations in the ORC6 subunit lead to Meier-Gorlin syndrome in humans.
    1. Structural Biology and Molecular Biophysics

    Structural basis of ClpXP recognition and unfolding of ssrA-tagged substrates

    Xue Fei, Tristan A Bell ... Robert T Sauer
    Cryo-EM structures of the AAA+ ClpXP protease bound to an ssrA degron reveal the mechanism of substrate recognition and show how the machine transitions from recognition to translocation and unfolding.
    1. Neuroscience

    Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition

    Paul Glad Mihai, Michelle Moerel ... Katharina von Kriegstein
    Ultra-high field neuroimaging dissects the ventral medial geniculate body (vMGB) of the primary auditory pathway from other MGB subregions and reveals that vMGB top-down modulation is relevant for speech recognition.
    1. Chromosomes and Gene Expression

    The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

    Hsiang-Chen Chou, Kuhulika Bhalla ... Bruce Stillman
    The initiation of human genome replication requires the six-subunit origin recognition complex (ORC) and CDC6, with ORC playing additional roles during mitosis and in organization of the cell nucleus.
    1. Medicine
    2. Neuroscience

    Recovery of consciousness and cognition after general anesthesia in humans

    George A Mashour, Ben JA Palanca ... Max B Kelz
    Cognitive reconstitution after pharmacologic unconsciousness is an extended process, executive function is more robust than expected, and the healthy human brain is resilient to the effects of deep general anesthesia.
    1. Computational and Systems Biology
    2. Neuroscience

    A computationally informed comparison between the strategies of rodents and humans in visual object recognition

    Anna Elisabeth Schnell, Maarten Leemans ... Hans Op de Beeck
    Using a computational approach for designing object recognition tasks is beneficial to highlight the different strategies among different species.
    1. Neuroscience

    Unsupervised changes in core object recognition behavior are predicted by neural plasticity in inferior temporal cortex

    Xiaoxuan Jia, Ha Hong, James J DiCarlo
    Temporal continuity-induced plasticity in individual neurons of inferior temporal cortex builds neural representations that underlie robust core object recognition behavior.
    1. Biochemistry and Chemical Biology

    High-throughput profiling of sequence recognition by tyrosine kinases and SH2 domains using bacterial peptide display

    Allyson Li, Rashmi Voleti ... Neel H Shah
    A high-throughput method to profile tyrosine kinases and phosphotyrosine recognition domains reveals new rules for sequence specificity and maps the effects of mutations on the recognition of tyrosine phosphorylation sites.
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter

    Ursula Schulze-Gahmen, Huasong Lu ... Tom Alber
    AFF4 increases the combined selectivity of HIV Tat and TAR for super elongation complexes 330-fold over P-TEFb alone.

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